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AVEN antibody (C-Term)

AVEN Reactivity: Human, Mouse, Rat WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN499367
  • Target See all AVEN Antibodies
    AVEN (Apoptosis, Caspase Activation Inhibitor (AVEN))
    Binding Specificity
    • 15
    • 13
    • 8
    • 5
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 48
    • 12
    • 5
    • 3
    Human, Mouse, Rat
    Host
    • 45
    • 3
    Rabbit
    Clonality
    • 44
    • 3
    Polyclonal
    Conjugate
    • 17
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This AVEN antibody is un-conjugated
    Application
    • 40
    • 22
    • 13
    • 13
    • 6
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody reacts to AVEN.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    Aven antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human Aven.
    Isotype
    IgG
    Top Product
    Discover our top product AVEN Primary Antibody
  • Application Notes
    ELISA. Western Blot: Aven antibody can be used for detection of Aven at 0.5 to 1 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    AVEN (Apoptosis, Caspase Activation Inhibitor (AVEN))
    Alternative Name
    AVEN (AVEN Products)
    Synonyms
    AVEN antibody, pdcd12 antibody, aven antibody, wu:fc08c09 antibody, si:ch211-150c22.4 antibody, PDCD12 antibody, 1700013A01Rik antibody, 1700056A21Rik antibody, mAven-L antibody, mAven-S antibody, apoptosis and caspase activation inhibitor antibody, apoptosis, caspase activation inhibitor L homeolog antibody, apoptosis, caspase activation inhibitor antibody, Aven antibody, AVEN antibody, aven.L antibody, aven antibody
    Background
    Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients. Despite its predicted molecular weight, Aven often migrates at 55 kDa in SDS-PAGE.Synonyms: Cell death regulator Aven, PDCD12, Programmed cell death 12
    Gene ID
    57099
    NCBI Accession
    NP_065104
    UniProt
    Q9NQS1
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