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UBQLN4 antibody (N-Term)

UBQLN4 Reactivity: Human, Mouse, Rat WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN499635
  • Target See all UBQLN4 Antibodies
    UBQLN4 (Ubiquilin 4 (UBQLN4))
    Binding Specificity
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 21
    • 14
    • 12
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 21
    Rabbit
    Clonality
    • 19
    • 2
    Polyclonal
    Conjugate
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This UBQLN4 antibody is un-conjugated
    Application
    • 14
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody reacts to CIP75.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    CIP75 antibody was raised against an 18 amino acid peptide near the amino terminus of human CIP75.
    Isotype
    IgG
    Top Product
    Discover our top product UBQLN4 Primary Antibody
  • Application Notes
    ELISA. Western Blot: CIP75 antibody can be used for detection of CIP75 at 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    UBQLN4 (Ubiquilin 4 (UBQLN4))
    Alternative Name
    Ubiquilin-4 (UBQLN4 Products)
    Synonyms
    a1u antibody, cip75 antibody, ubin antibody, ubiquilin-4 antibody, A1U antibody, A1Up antibody, C1orf6 antibody, CIP75 antibody, UBIN antibody, A1u antibody, AI663987 antibody, RGD1308273 antibody, ubiquilin 4 L homeolog antibody, ubiquilin 4 antibody, ubqln4.L antibody, ubqln4 antibody, UBQLN4 antibody, Ubqln4 antibody
    Background
    The ubiquitin-proteosome pathway of protein degradation is one of the mechanisms that ensure the proper level of cellular proteins. The ubiquitin-like (UbL) and ubiquitin-associated (UBA) domain containing protein family is thought to be involved in proteosomal degradation. One such protein is CIP75, also known as ubiquilin-4, interacts with a number of proteins such as Ataxin-1 and Connexin-43, resulting in an increased rate of turnover of these proteins. Overexpression CIP75 led to a significant reduction of Connexin-43 half-life, with the opposite being observed in siRNA knockdown experiments. CIP75 contains an N-terminal UbL domain which is thought to interact with proteins of the 26S proteosome complex and a C-terminal UBA domain which appears to mediate its interaction with Connexin-75. At least three isoforms of CIP75 are known to exist.Synonyms: A1Up, Ataxin-1 interacting ubiquitin-like protein, Ataxin-1 ubiquitin-like-interacting protein A1U, C1orf6, CIP75, Connexin43-interacting protein of 75 kDa, UBIN, UBQLN4
    Gene ID
    56893
    UniProt
    Q9NRR5
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