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DcR1 antibody

TNFRSF10C Reactivity: Human, Mouse, Rat WB, IF, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN499722
  • Target See all DcR1 (TNFRSF10C) Antibodies
    DcR1 (TNFRSF10C) (Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C))
    Reactivity
    • 59
    • 6
    • 6
    • 6
    Human, Mouse, Rat
    Host
    • 40
    • 24
    • 1
    • 1
    Rabbit
    Clonality
    • 42
    • 24
    Polyclonal
    Conjugate
    • 32
    • 8
    • 6
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DcR1 antibody is un-conjugated
    Application
    • 39
    • 24
    • 24
    • 13
    • 13
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Specificity
    DcR1 antibody was raised against a peptide corresponding to amino acids in the extracellular domain of human DcR1 precursor.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    Human DcR1 Peptide
    Isotype
    IgG
    Top Product
    Discover our top product TNFRSF10C Primary Antibody
  • Application Notes
    ELISA. Western Blot: 0.5 to 1 μg/mL. An approximate 65 kDa band can be detected. Immunofluorescence.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C.
  • Target
    DcR1 (TNFRSF10C) (Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C))
    Alternative Name
    CD263 / TRAILR3 (TNFRSF10C Products)
    Synonyms
    CD263 antibody, DCR1 antibody, DCR1-TNFR antibody, LIT antibody, TRAIL-R3 antibody, TRAILR3 antibody, TRID antibody, TNFRSF10C antibody, TNF receptor superfamily member 10c antibody, TNFRSF10C antibody
    Background
    Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL (1-3). Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT (2-7) and DcR2/TRAIL-R4/TRUNDD (8-10). DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts are expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.Synonyms: Antagonist decoy receptor for TRAIL/Apo-2L, DCR1, Decoy TRAIL receptor without death domain, Decoy receptor 1, LIT, Lymphocyte inhibitor of TRAIL, TNF-related apoptosis-inducing ligand receptor 3, TNFRSF10C, TRAIL receptor 3, TRAIL-R3, TRID, Trail receptor without an intracellular domain, Tumor necrosis factor receptor superfamily member 10C
    Gene ID
    8794
    UniProt
    O14798
    Pathways
    Apoptosis
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