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PIAS1 antibody (C-Term)

PIAS1 Reactivity: Human, Mouse, Rat WB, IHC (p), IF, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN500489
  • Target See all PIAS1 Antibodies
    PIAS1 (Protein Inhibitor of Activated STAT, 1 (PIAS1))
    Binding Specificity
    • 11
    • 10
    • 8
    • 6
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 49
    • 11
    • 7
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 46
    • 4
    Rabbit
    Clonality
    • 46
    • 4
    Polyclonal
    Conjugate
    • 28
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PIAS1 antibody is un-conjugated
    Application
    • 41
    • 25
    • 24
    • 9
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Specificity
    This antibody is predicted to not cross-react with other members of the PIAS family.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, Mouse, Rat.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    15 amino acid peptide near the carboxy terminus of Human PIAS1.
    Isotype
    IgG
    Top Product
    Discover our top product PIAS1 Primary Antibody
  • Application Notes
    ELISA. Western blot: 1 - 2 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % Sodium Azide as preservative
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    PIAS1 (Protein Inhibitor of Activated STAT, 1 (PIAS1))
    Alternative Name
    PIAS1 (PIAS1 Products)
    Synonyms
    2900068C24Rik antibody, Ddxbp1 antibody, GBP antibody, DDXBP1 antibody, GU/RH-II antibody, ZMIZ3 antibody, ddxbp1 antibody, gbp antibody, pias antibody, pias1-A antibody, xPAIS1 antibody, xPIAS1 antibody, zmiz3 antibody, protein inhibitor of activated STAT 1 antibody, protein inhibitor of activated STAT, 1 antibody, protein inhibitor of activated STAT, 1a antibody, protein inhibitor of activated STAT 1 L homeolog antibody, PIAS1 antibody, Pias1 antibody, pias1a antibody, pias1.L antibody
    Background
    The PIAS proteins (protein inhibitor of activated STAT) play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS1. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS1 binds specifically to STAT1, inhibiting STAT1-mediated gene activation and also binds to the Gu/RNA helicase II enzyme, leading to the proteolytic cleavage of Gu/RH-II. PIAS1 is a potent co-activator for CP2c-mediated ?-globin expression in erythroid cells.Synonyms: DDXBP1, DEAD/H box-binding protein 1, E3 SUMO-protein ligase PIAS1, Gu-binding protein, PIAS-1, Protein inhibitor of activated STAT protein 1, RNA helicase II-binding protein
    Gene ID
    8554
    NCBI Accession
    NP_057250
    UniProt
    O75925
    Pathways
    JAK-STAT Signaling, Interferon-gamma Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation, Hepatitis C
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