PPAPDC1B antibody (N-Term)

Catalog No. ABIN500529

Product Details anti-PPAPDC1B Antibody

Target: PPAPDC1B (Phosphatidic Acid Phosphatase Type 2 Domain Containing 1B (PPAPDC1B))

Binding Specificity: N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPAPDC1B antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects PPAPDC1B.

Purification: Peptide affinity chromatography

Immunogen: PPAPDC1B antibody was raised against a 14 amino acid peptide near the amino terminus of human PPAPDC1B.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PPAPDC1B

Target: PPAPDC1B (Phosphatidic Acid Phosphatase Type 2 Domain Containing 1B (PPAPDC1B))

Alternative Name: PPAPDC1B (PPAPDC1B Products)

Synonyms: PPAPDC1B antibody, DPPL1 antibody, HTPAP antibody, 1810019D05Rik antibody, 2310022A04Rik antibody, AW045471 antibody, Ppapdc1 antibody, phospholipid phosphatase 5 antibody, PLPP5 antibody, plpp5 antibody, Plpp5 antibody

Background: Phosphatidate phosphatase (PAP) plays important role in lipid-signaling metabolism in eukaryotic cells. Two distinct types of PAP (PAP1 and PAP2) activity have been distinguished by their subcellular localization and differential sensitivity to N-ethylmaleimide (NEM) and Mg2+. A yeast diacylglycerol pyrophosphate (DGPP) phosphatase (DPP1) and mammalian DGPP phosphatase (PAP2) have been identified as Mg2+-independent and NEM-insensitive membrane-associated. PPAPDC1A (also known as DPPL2) and PPAPDC1B (DPPL1) form a novel type of Mg2+-independent and NEM-sensitive mammalian phosphatidate phosphatase showing broad substrate specificity. Knockdown experiments indicated that this protein is involved with multiple cell signaling pathways, including the JAK-Stat3, MAP kinase, and PKC pathways. PPAPDC1B may also potentiate the estrogen receptor pathway by down-regulating DUSP22.Synonyms: DPPL1, HTPAP, Phosphatidate phosphatase PPAPDC1B, Phosphatidic acid phosphatase type 2 domain-containing protein 1B

Gene ID: 84513

NCBI Accession: NP_001096029

UniProt: Q8NEB5