FAIM3 antibody (C-Term)

Catalog No. ABIN501016

Product Details anti-FAIM3 Antibody

Target: FAIM3 (Fas Apoptotic Inhibitory Molecule 3 (FAIM3))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FAIM3 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects FAIM3 / TOSO.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Affinity chromatography

Immunogen: Toso antibody was raised against a 13 amino acid peptide from near the carboxy terminus of human Toso.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for FAIM3

Target: FAIM3 (Fas Apoptotic Inhibitory Molecule 3 (FAIM3))

Alternative Name: FAIM3 / TOSO (FAIM3 Products)

Synonyms: FAIM3 antibody, FCMR antibody, TOSO antibody, 1810037B05Rik antibody, FcmuR antibody, Toso antibody, Fc fragment of IgM receptor antibody, FCMR antibody, Fcmr antibody

Background: Apoptosis is an important process by which normal tissue homeostasis and function are maintained. One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand. This leads to the formation of a Fas-associated death domain (FADD)- containing death-inducing signaling complex and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7. Recent experiments have shown that overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, in Jurkat cells as well as transgenic mice render these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex. Despite its predicted molecular weight, Toso often migrates at 60 kDa in SDS-PAGE.Synonyms: Fas apoptotic inhibitory molecule 3, Regulator of Fas-induced apoptosis Toso

Gene ID: 9214

NCBI Accession: NP_005440