KCNK18 antibody (Center)

Catalog No. ABIN501034

Product Details anti-KCNK18 Antibody

Target: KCNK18 (Potassium Channel Subfamily K Member 18 (KCNK18))

Binding Specificity: Center

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNK18 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogen: TRESK antibody was raised against a 17 amino acid peptide from near the center of human TRESK.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for KCNK18

Target: KCNK18 (Potassium Channel Subfamily K Member 18 (KCNK18))

Alternative Name: KCNK18 (KCNK18 Products)

Synonyms: K2p18.1 antibody, MGR13 antibody, TRESK antibody, TRESK-2 antibody, TRESK2 antibody, TRIK antibody, Gm781 antibody, Tresk antibody, Tresk-2 antibody, Trik antibody, potassium two pore domain channel subfamily K member 18 antibody, potassium channel, subfamily K, member 18 antibody, KCNK18 antibody, Kcnk18 antibody

Background: TRESK (TWIK-related spinal cord K+ channel) is a two-pore domain K+ channel that induces outward rectification and functions as a background K+ channel that is abundantly expressed in the spinal cord, thymus, spleen, and leukemic T-lymphocytes. TRESK is activated by increased cytoplasmic calcium concentration through calcineurin as well as by acetylcholine and histamine. It has been suggested that TRESK is linked to acute and chronic pain by activation of calcineurin. Other studies indicate that TRESK may play a role in the regulation of T-cell function and could be an excellent target to treat T-cell originated immune dysfunction.Synonyms: KCNK18, Potassium channel subfamily K member 18, TRESK, TRIK, TWIK-related individual potassium channel, TWIK-related spinal cord potassium channel

Gene ID: 338567

NCBI Accession: NP_862823