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XAF1 antibody (Middle Region)

XAF1 Reactivity: Human WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN501128
  • Target See all XAF1 Antibodies
    XAF1 (XiAP Associated Factor 1 (XAF1))
    Binding Specificity
    • 7
    • 5
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 38
    • 13
    • 4
    • 2
    Human
    Host
    • 35
    • 11
    Rabbit
    Clonality
    • 37
    • 9
    Polyclonal
    Conjugate
    • 22
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This XAF1 antibody is un-conjugated
    Application
    • 26
    • 15
    • 7
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects XAF-1 at Center.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human
    Purification
    Affinity chromatography
    Immunogen
    XAF-1 antibody was raised against a synthetic peptide corresponding to 16 amino acids near the middle of human XAF-1.
    Isotype
    IgG
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    Discover our top product XAF1 Primary Antibody
  • Application Notes
    ELISA. Western blot: 1-2 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    XAF1 (XiAP Associated Factor 1 (XAF1))
    Alternative Name
    XAF1 (XAF1 Products)
    Synonyms
    BIRC4BP antibody, HSXIAPAF1 antibody, XIAPAF1 antibody, Fbxo39 antibody, XIAP associated factor 1 antibody, xaf1 antibody, XAF1 antibody, Xaf1 antibody
    Background
    XAF-1 binds to XIAP, an inhibitor of caspases-3, -7, and -9, and triggers its relocation from the cytosol to the nucleus (1,2). Overexpression of XAF-1 results in the neutralization of XIAP's ability to inhibit cell death (1). XAF-1 is normally expressed in all adult and fetal tissues but was found to be present in very low levels in a variety of cancer cell lines (3). In contrast, XIAP levels have been shown to be high in a majority of cell lines. Low XAF-1 and high basal expression of XIAP may therefore play a critical role in maintaining survival of cancer cell lines (2,3). Both IFN-α2 and IFN-β can induce XAF-1 mRNA in all cells examined but induction of XAF-1 protein (as observed by immunoblot analysis) was seen only in cell lines sensitive to the apoptotic effects of IFNs (4).Synonyms: BIRC4-binding protein, BIRC4BP, XIAP-associated factor 1, XIAPAF1
    Gene ID
    54739
    NCBI Accession
    NP_059993
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