This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.Synonyms: AML2, Acute myeloid leukemia 2 protein, CBF-alpha-3, CBFA3, Core-binding factor subunit alpha-3, Oncogene AML-2, PEA2-alpha C, PEBP2-alpha C, PEBP2A3, Polyomavirus enhancer-binding protein 2 alpha C subunit, Runt-related transcription factor 3, SL3-3 enhancer factor 1 alpha C subunit, SL3/AKV core-binding factor alpha C subunit