SEC62 antibody (C-Term)

Catalog No. ABIN1450053

Product Details anti-SEC62 Antibody

Target: SEC62 (TLOC1) (Translocation Protein 1 (TLOC1))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SEC62 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse, Rat.

Purification: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid synthetic peptide near the carboxy terminus of Human SEC62

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for SEC62

Target: SEC62 (TLOC1) (Translocation Protein 1 (TLOC1))

Alternative Name: SEC62 / TLOC1 (TLOC1 Products)

Synonyms: tloc1 antibody, TLOC1 antibody, wu:fb57b06 antibody, zgc:114073 antibody, Dtrp1 antibody, HTP1 antibody, TP-1 antibody, 3100002M17Rik antibody, AI844545 antibody, AW545092 antibody, Tloc1 antibody, Ab2-292 antibody, SEC62 homolog, preprotein translocation factor S homeolog antibody, SEC62 homolog, preprotein translocation factor antibody, membrane unit of ER protein translocation apparatus antibody, SEC62 homolog (S. cerevisiae) antibody, sec62.S antibody, SEC62 antibody, sec62 antibody, Sec62 antibody

Background: SEC62 is an integral membrane protein located in the rough endoplasmic reticulum (ER) and is part of the SEC61-SEC62-SEC63 complex that is the central component of the protein translocation apparatus of the ER membrane. It is speculated that SEC61-SEC62-SEC63 may perform post-translational protein translocation into the ER and might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. Silencing of this gene with RNAi dramatically reduced the migration and invasive potential of numerous tumor cell lines, suggesting that it may be an attractive target for therapy of various tumors.Synonyms: Translocation protein 1, Translocation protein SEC62

Gene ID: 7095

NCBI Accession: NP_003253