E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) (AA 33-282) antibody

Details for Product No. ABIN556345
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Antigen
Synonyms SIAH, Siah1, Siah1a, id:ibd2635, zgc:56026, SIAH1A, siah
Epitope
AA 33-282
(15), (8), (8), (4), (2), (1), (1), (1), (1)
Reactivity
Human
(68), (32), (29), (19), (18), (14), (12), (4), (3), (2), (2)
Host
Rabbit
(57), (9), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(59), (32), (14), (10), (5), (3), (2), (2), (1)
Pubmed 4 references available
Quantity 0.1 mL
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Catalog No. ABIN556345
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Immunogen Recombinant fragment corresponding to a region within amino acids 33 and 282 of SIAH1
Isotype IgG
Predicted Reactivity Chimpanzee (100%), Bovine (100%)
Characteristics Cellular Localization: Cytoplasm , Nucleus
Purification Purified by antigen-affinity chromatography..
Alternative Name SIAH1
Background This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq]
Synonyms: FLJ08065 antibody, SIAH1A antibody, SIAH1 antibody, siah-1a antibody, E3 ubiquitin-protein ligase SIAH1 antibody, seven in absentia homolog 1 (Drosophila) antibody
Molecular Weight 31 kDa
UniProt Q8IUQ4
Research Area Proteolysis / Ubiquitin
Comment

Positive Controls: U87-MG

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Solomon: "The function(s) of CAK, the p34cdc2-activating kinase." in: Trends in biochemical sciences, Vol. 19, Issue 11, pp. 496-500, 1995 (PubMed).

Tassan, Schultz, Bartek et al.: "Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase)." in: The Journal of cell biology, Vol. 127, Issue 2, pp. 467-78, 1994 (PubMed).

Fisher, Morgan: "A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase." in: Cell, Vol. 78, Issue 4, pp. 713-24, 1994 (PubMed).

Mäkelä, Tassan, Nigg et al.: "A cyclin associated with the CDK-activating kinase MO15." in: Nature, Vol. 371, Issue 6494, pp. 254-7, 1994 (PubMed).

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