Ubiquitin Protein Ligase E3A (ube3a) (AA 1-249) antibody

Details for Product No. ABIN556358
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Antigen
Synonyms
AS, As, CG6190, Dmel\\CG6190, Dube3a, UBE3A, dUBE3A, das, dube3A, dube3a, DDBDRAFT_0188760, DDBDRAFT_0302447, DDB_0188760, DDB_0302447, DKFZp459N106, ube3a, MGC69536, ANCR, E6-AP, EPVE6AP, HPVE6A, 473 ... show more
AS, As, CG6190, Dmel\\CG6190, Dube3a, UBE3A, dUBE3A, das, dube3A, dube3a, DDBDRAFT_0188760, DDBDRAFT_0302447, DDB_0188760, DDB_0302447, DKFZp459N106, ube3a, MGC69536, ANCR, E6-AP, EPVE6AP, HPVE6A, 4732496B02, 5830462N02Rik, A130086L21Rik, Hpve6a, mKIAA4216, im:7140733, zgc:92173, UME3A show less
Epitope
AA 1-249
(11), (7), (6), (6), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(63), (21), (17), (14), (12), (12), (2), (2), (1), (1)
Host
Rabbit
(53), (10)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(54), (24), (19), (10), (10), (9), (8), (7), (6), (1)
Pubmed 2 references available
Quantity 0.1 mL
Shipping to United States (Change)
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Catalog No. ABIN556358
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Immunogen Recombinant fragment corresponding to a region within amino acids 1 and 249 of E6-AP
Isotype IgG
Predicted Reactivity Human (100%), Rhesus Monkey (100%)
Characteristics Cellular Localization: Nucleus
Purification Purified by antigen-affinity chromatography..
Alternative Name UBE3A
Background This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq]
Synonyms: ANCR antibody, AS antibody, E6-AP antibody, EPVE6AP antibody, FLJ26981 antibody, HPVE6A antibody, UBE3A antibody, CTCL tumor antigen se37-2 antibody, ubiquitin-protein ligase E3A antibody, oncogenic protein-associated protein E6-AP antibody, human papillomavirus E6-associated protein antibody, E6AP ubiquitin-protein ligase antibody, human papilloma virus E6-associated protein antibody, renal carcinoma antigen NY-REN-54 antibody, ubiquitin protein ligase E3A antibody
Molecular Weight 101 kDa
UniProt Q05086
Research Area Chromatin and Nuclear Signaling, Proteolysis / Ubiquitin
Comment

Positive Controls: Target recombinant protein

Restrictions For Research Use only
Format Liquid
Concentration 0.84 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Miyashita, Krajewski, Krajewska et al.: "Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo." in: Oncogene, Vol. 9, Issue 6, pp. 1799-805, 1994 (PubMed).

Dias, Dilling, Houghton: "The molecular basis of skeletal muscle differentiation." in: Seminars in diagnostic pathology, Vol. 11, Issue 1, pp. 3-14, 1994 (PubMed).

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