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tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, beta Polypeptide (YWHAB) (AA 34-246), (AA 34-246) antibody

Details for Product No. ABIN556362
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Antigen
Synonyms hs1, gw128, kcip-1, 14-3-3beta, 1433b, YWHAB, DKFZp459L1720, GW128, HS1, KCIP-1, YWHAA, 1300003C17Rik
Epitope
AA 34-246, AA 34-246
(20), (12), (9), (7), (6), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(118), (46), (42), (14), (13), (13), (12), (5), (3), (1), (1), (1)
Host
Rabbit
(95), (30)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (5), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(112), (59), (34), (25), (16), (15), (10), (9), (1)
Pubmed 3 references available
Quantity 0.1 mL
Shipping to United States (Change)
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Catalog No. ABIN556362
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Immunogen Recombinant fragment corresponding to a region within amino acids 34 and 246 of 14-3-3 beta
Cross-Reactivity Mouse (Murine)
Predicted Reactivity Rhesus Monkey (100%), Bovine (100%)
Characteristics Cellular Localization: Cytoplasm , Melanosome
Purification Purified by antigen-affinity chromatography..
Alternative Name 14-3-3 protein beta/alpha
Background This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq]
Synonyms: GW128 antibody, HS1 antibody, KCIP-1 antibody, YWHAA antibody, YWHAB antibody, "brain protein 14-3-3, beta isoform antibody", protein 1054 antibody, 14-3-3 protein beta/alpha antibody, protein kinase C inhibitor protein-1 antibody, "tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide antibody", 14-3-3 alpha antibody, protein kinase C inhibitor protein 1 antibody, "tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide antibody"
Molecular Weight 28 kDa
UniProt P31946
Research Area Transcription Factors
Comment

Positive Controls: 293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji , mouse brain

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Tewari, Quan, ORourke et al.: "Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase." in: Cell, Vol. 81, Issue 5, pp. 801-9, 1995 (PubMed).

Kaufmann, Desnoyers, Ottaviano et al.: "Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis." in: Cancer research, Vol. 53, Issue 17, pp. 3976-85, 1993 (PubMed).

Patel, Gores, Kaufmann: "The role of proteases during apoptosis." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 10, Issue 5, pp. 587-97, 1996 (PubMed).

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