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Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3) (AA 171-316), (AA 121-346) antibody

Details for Product No. ABIN556370
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Antigen
Synonyms EIF2AK3, AI427929, Pek, Perk, PEK, PERK, WRS
Epitope
AA 171-316, AA 121-346
(22), (20), (11), (6), (6), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(90), (48), (42), (12), (12), (12)
Host
Rabbit
(86), (10), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (6), (6), (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(60), (48), (42), (20), (18), (9), (6), (4)
Pubmed 2 references available
Quantity 0.1 mL
Shipping to United States (Change)
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Catalog No. ABIN556370
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Immunogen Recombinant fragment corresponding to a region within amino acids 121 and 346 of PERK
Isotype IgG
Cross-Reactivity Human, Rat (Rattus)
Predicted Reactivity Human (100%)
Purification Purified by antigen-affinity chromatography..
Alternative Name EIF2AK3
Background The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq]
Synonyms: DKFZp781H1925 antibody, PEK antibody, PERK antibody, WRS antibody, EIF2AK3 antibody, hsPEK antibody, eukaryotic translation initiation factor 2-alpha kinase 3 antibody, PRKR-like endoplasmic reticulum kinase antibody, pancreatic EIF2-alpha kinase antibody, eukaryotic translation initiation factor 2 alpha kinase 3 antibody
Molecular Weight 125 kDa
UniProt Q9NZJ5
Comment

Positive Controls: Target recombinant protein

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Takahashi, Tanaka, Brannan et al.: "Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand." in: Cell, Vol. 76, Issue 6, pp. 969-76, 1994 (PubMed).

Tanaka, Suda, Takahashi et al.: "Expression of the functional soluble form of human fas ligand in activated lymphocytes." in: The EMBO journal, Vol. 14, Issue 6, pp. 1129-35, 1995 (PubMed).

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