Dihydrolipoamide Branched Chain Transacylase E2 (DBT) (AA 11-247) antibody

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Antigen
Synonyms BCATE2, BCKAD-E2, BCKADE2, E2, E2B, D3Wsu60e, im:7147214, zgc:103768, E2b
Epitope
AA 11-247
(3), (2)
Reactivity
Human
(11), (4), (4), (1), (1), (1), (1), (1)
Host
Rabbit
(9), (3)
Clonality
Polyclonal
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(12), (2), (2), (2), (1), (1)
Pubmed 2 references available
Quantity 0.1 mL
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Catalog No. ABIN556431
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Immunogen Recombinant fragment corresponding to a region within amino acids 11 and 247 of DBT
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Predicted Reactivity Rhesus Monkey (100%), Chimpanzee (100%)
Characteristics Cellular Localization: Mitochondrion matrix
Purification Purified by antigen-affinity chromatography..
Alternative Name DBT
Background The branched-chain alpha-keto acid dehydrogenase complex (BCKD) is an inner-mitochondrial enzyme complex involved in the breakdown of the branched-chain amino acids isoleucine, leucine, and valine. The BCKD complex is thought to be composed of a core of 24 transacylase (E2) subunits, and associated decarboxylase (E1), dehydrogenase (E3), and regulatory subunits. This gene encodes the transacylase (E2) subunit. Mutations in this gene result in maple syrup urine disease, type 2. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq]
Synonyms: BCATE2 antibody, E2 antibody, E2B antibody, MGC9061 antibody, DBT antibody, BCKAD E2 subunit antibody, dihydrolipoyllysine-residue (2-methylpropanoyl)transferase antibody, dihydrolipoyl transacylase antibody, mitochondrial branched chain alpha-keto acid dehydrogenase transacylase subunit (E2b) antibody, lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial antibody, branched chain acyltransferase, E2 component antibody, BCKAD-E2 antibody, dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex antibody, branched-chain alpha-keto acid dehydrogenase complex component E2 antibody, lipoamide acyltransferase component of mitochondrial branched-chain alpha-keto acid dehydrogenase complex antibody, BCKADE2 antibody, E2 component of branched chain alpha-keto acid dehydrogenase complex antibody, dihydrolipoamide branched chain transacylase E2 antibody
Molecular Weight 53 kDa
UniProt P11182
Research Area Signaling, Metabolism, Organelles
Comment

Positive Controls: H1299 , HepG2 , mouse liver , rat liver

Restrictions For Research Use only
Format Liquid
Concentration 0.33 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Fredersdorf, Milne, Hall et al.: "Characterization of a panel of novel anti-p21Waf1/Cip1 monoclonal antibodies and immunochemical analysis of p21Waf1/Cip1 expression in normal human tissues." in: The American journal of pathology, Vol. 148, Issue 3, pp. 825-35, 1997 (PubMed).

Levine: "p53, the cellular gatekeeper for growth and division." in: Cell, Vol. 88, Issue 3, pp. 323-31, 1997 (PubMed).

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