RAB8A, Member RAS Oncogene Family (RAB8A) (AA 1-134) antibody

Details for Product No. ABIN556466
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Antigen
Synonyms rab8A, DDBDRAFT_0206521, DDBDRAFT_0214885, DDB_0206521, DDB_0214885, HSH2D, mel, rab8, c-mel, MEL, RAB8, zgc:162699, AA409338, Mel, Rab8
Epitope
AA 1-134
(8), (7), (2), (1), (1), (1), (1)
Reactivity
Human
(43), (20), (19), (16), (14), (3), (2), (1), (1)
Host
Rabbit
(27), (9), (8)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(33), (17), (10), (8), (6), (3), (1), (1), (1)
Pubmed 2 references available
Quantity 0.1 mL
Shipping to United States (Change)
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Catalog No. ABIN556466
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Immunogen Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 134 of RAB8A
Isotype IgG
Predicted Reactivity Human (100%), Mouse (100%), Rat (100%), Dog (100%), Pig (100%), Sheep (100%), Chimpanzee (100%), Bovine (100%)
Characteristics Cellular Localization: Cell membrane, Lipid-anchor, Cytoplasmic side
Purification Purified by antigen-affinity chromatography..
Alternative Name RAB8A
Background The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq]
Synonyms: MEL antibody, RAB8 antibody, RAB8A antibody, mel transforming oncogene (derived from cell line NK14)- RAB8 homolog antibody, oncogene c-mel antibody, mel transforming oncogene (RAB8 homolog) antibody, ras-related protein Rab-8A antibody, ras-associated protein RAB8 antibody, mel transforming oncogene (derived from cell line NK14) antibody, "RAB8A, member RAS oncogene family antibody"
Molecular Weight 24 kDa
Research Area Signaling
Comment

Positive Controls: Target recombinant protein

Restrictions For Research Use only
Format Liquid
Concentration 0.53 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Muzio, Chinnaiyan, Kischkel et al.: "FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex." in: Cell, Vol. 85, Issue 6, pp. 817-27, 1996 (PubMed).

Thome, Schneider, Hofmann et al.: "Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors." in: Nature, Vol. 386, Issue 6624, pp. 517-21, 1997 (PubMed).

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