MHC Class I Polypeptide-Related Sequence A (MICA) (AA 79-300) antibody

Details for Product No. ABIN556467
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Antigen
Synonyms Ica, mICA, FLJ60820, PERB11.1, MGC111087, MIC-A
Epitope
AA 79-300
(9), (7), (5), (3), (2), (2), (2), (1), (1), (1)
Reactivity
Human
(84), (10), (6), (6), (4)
Host
Rabbit
(55), (27), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (5), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(50), (27), (27), (18), (10), (10), (7), (7), (6), (3), (2), (2), (1)
Pubmed 3 references available
Quantity 0.1 mL
Shipping to United States (Change)
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Catalog No. ABIN556467
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Immunogen Recombinant protein fragment contain a sequence corresponding to a region within amino acids 79 and 300 (Q29983) of MICA
Isotype IgG
Predicted Reactivity Human (99%)
Characteristics Cellular Localization: Cell membrane, Single-pass type I membrane protein , Cytoplasm
Purification Purified by antigen-affinity chromatography..
Alternative Name MICA
Background MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. [provided by RefSeq]
Synonyms: stress inducible class I homolog antibody, MHC class I chain-related protein A antibody, HLA class I antigen antibody, MHC class I polypeptide-related sequence A antibody
Molecular Weight 43 kDa
Research Area Immunology, Innate Immunity, Adaptive Immunity
Comment

Positive Controls: Target recombinant protein

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Reed: "Bcl-2 and the regulation of programmed cell death." in: The Journal of cell biology, Vol. 124, Issue 1-2, pp. 1-6, 1994 (PubMed).

Oltvai, Milliman, Korsmeyer: "Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death." in: Cell, Vol. 74, Issue 4, pp. 609-19, 1993 (PubMed).

Hsu, Wolter, Youle: "Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 8, pp. 3668-72, 1997 (PubMed).

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