Methylenetetrahydrofolate Reductase (NAD(P)H) (MTHFR) (AA 21-248) antibody

Details for Product No. ABIN556468
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Antigen
Synonyms DDBDRAFT_0204686, DDBDRAFT_0230137, DDB_0204686, DDB_0230137, AI323986
Epitope
AA 21-248
(12), (9), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(59), (22), (18), (13), (13), (13), (1)
Host
Rabbit
(37), (17), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(47), (32), (10), (9), (6), (4), (3), (2)
Pubmed 5 references available
Quantity 0.1 mL
Shipping to United States (Change)
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Catalog No. ABIN556468
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Immunogen Recombinant fragment corresponding to a region within amino acids 21 and 248 of MTHFR
Isotype IgG
Predicted Reactivity Mouse (89%), Bovine (89%)
Purification Purified by antigen-affinity chromatography..
Alternative Name MTHFR
Background Methylenetetrahydrofolate reductase (EC 1.5.1.20) catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine.[supplied by OMIM]
Synonyms: MTHFR antibody, "5,10-methylenetetrahydrofolate reductase (NADPH) antibody", methylenetetrahydrofolate reductase antibody, methylenetetrahydrofolate reductase (NAD(P)H) antibody
Molecular Weight 75 kDa
UniProt P42898
Research Area Signaling, Metabolism, Amino Acids
Comment

Positive Controls: 293T

Restrictions For Research Use only
Format Liquid
Concentration 0.63 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Pitti, Marsters, Ruppert et al.: "Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family." in: The Journal of biological chemistry, Vol. 271, Issue 22, pp. 12687-90, 1996 (PubMed).

Marsters, Pitti, Donahue et al.: "Activation of apoptosis by Apo-2 ligand is independent of FADD but blocked by CrmA." in: Current biology : CB, Vol. 6, Issue 6, pp. 750-2, 1997 (PubMed).

Mariani, Matiba, Armandola et al.: "Interleukin 1 beta-converting enzyme related proteases/caspases are involved in TRAIL-induced apoptosis of myeloma and leukemia cells." in: The Journal of cell biology, Vol. 137, Issue 1, pp. 221-9, 1997 (PubMed).

Sheridan, Marsters, Pitti et al.: "Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors." in: Science (New York, N.Y.), Vol. 277, Issue 5327, pp. 818-21, 1997 (PubMed).

Wang, Wang, Hernandez et al.: "Regulation of TRAIL expression by the phosphatidylinositol 3-kinase/Akt/GSK-3 pathway in human colon cancer cells." in: The Journal of biological chemistry, Vol. 277, Issue 39, pp. 36602-10, 2002 (PubMed).

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