SH3-Domain GRB2-Like 1 (SH3GL1) (AA 152-368) antibody

Details for Product No. ABIN556496
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Antigen
Synonyms cb831, sh3gl1, MGC78966, MGC130739, CNSA1, EEN, SH3D2B, SH3P8, C77078, Sh3d2b
Epitope
AA 152-368
(19), (8), (7), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(34), (23), (5), (2), (1), (1)
Host
Rabbit
(34), (16), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(52), (26), (24), (21), (15), (4), (2), (2), (1), (1)
Pubmed 3 references available
Quantity 0.1 mL
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Catalog No. ABIN556496
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Immunogen Recombinant fragment corresponding to a region within amino acids 152 and 368 of EEN
Predicted Reactivity Mouse (89%), Chicken (85%), Rat (87%), Bovine (93%)
Characteristics Cellular Localization: Cytoplasm (By similarity) , Early endosome membrane, Peripheral membrane protein (By similarity)
Purification Purified by antigen-affinity chromatography..
Alternative Name Endophilin-A2
Background This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq]
Synonyms: CNSA1 antibody, EEN antibody, MGC111371 antibody, SH3D2B antibody, SH3P8 antibody, SH3GL1 antibody, extra eleven-nineteen leukemia fusion gene protein antibody, endophilin-2 antibody, SH3 domain protein 2B antibody, endophilin-A2 antibody, SH3-containing Grb-2-like 1 protein antibody, SH3 domain-containing GRB2-like protein 1 antibody, extra 11-19 leukemia fusion antibody, EEN fusion partner of MLL antibody, SH3-domain GRB2-like 1 antibody
Molecular Weight 41 kDa
UniProt Q99961
Comment

Positive Controls: 293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Hsu, Xiong, Goeddel: "The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation." in: Cell, Vol. 81, Issue 4, pp. 495-504, 1995 (PubMed).

Hsu, Shu, Pan et al.: "TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways." in: Cell, Vol. 84, Issue 2, pp. 299-308, 1996 (PubMed).

Varfolomeev, Boldin, Goncharov et al.: "A potential mechanism of "cross-talk" between the p55 tumor necrosis factor receptor and Fas/APO1: proteins binding to the death domains of the two receptors also bind to each other." in: The Journal of experimental medicine, Vol. 183, Issue 3, pp. 1271-5, 1996 (PubMed).

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