Major Vault Protein (MVP) (AA 158-380) antibody

Details for Product No. ABIN556522
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Antigen
Synonyms
mvp, MGC145641, Tb05.45E22.810, DDBDRAFT_0190582, DDBDRAFT_0191259, DDB_0190582, DDB_0191259, DDBDRAFT_0189284, DDBDRAFT_0191337, DDB_0189284, DDB_0191337, LRP, VAULT1, 2310009M24Rik, cb771, wu:fb52b0 ... show more
mvp, MGC145641, Tb05.45E22.810, DDBDRAFT_0190582, DDBDRAFT_0191259, DDB_0190582, DDB_0191259, DDBDRAFT_0189284, DDBDRAFT_0191337, DDB_0189284, DDB_0191337, LRP, VAULT1, 2310009M24Rik, cb771, wu:fb52b05, wu:fc02g01 show less
Epitope
AA 158-380
(10), (9), (6), (3), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(115), (24), (20), (13), (13), (12), (12), (1), (1)
Host
Rabbit
(68), (44), (8)
Clonality
Polyclonal
Conjugate
Un-conjugated
(7), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(88), (53), (40), (38), (31), (28), (21), (15), (13), (10), (10)
Pubmed 8 references available
Quantity 0.1 mL
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Catalog No. ABIN556522
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Immunogen Recombinant fragment corresponding to a region within amino acids 158 and 380 of MVP/LRP
Cross-Reactivity Mouse (Murine)
Characteristics Cellular Localization: Cytoplasm , Nucleus , nuclear pore complex
Purification Purified by antigen-affinity chromatography..
Alternative Name Major Vault Protein
Background This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences, however, the open reading frames are the same in both transcripts. [provided by RefSeq]
Synonyms: LRP antibody, VAULT1 antibody, MVP antibody, lung resistance-related protein antibody, major vault protein antibody
Molecular Weight 99 kDa
UniProt Q14764
Research Area Enzymes, Metabolism, Cancer
Comment

Positive Controls: Molt-4 , Neuro2A , GL261 , C8D30 , BCL-1 , Raw264.7

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Deed, Jasiok, Norton: "Nucleotide sequence of the cDNA encoding human helix-loop-helix Id-1 protein: identification of functionally conserved residues common to Id proteins." in: Biochimica et biophysica acta, Vol. 1219, Issue 1, pp. 160-2, 1994 (PubMed).

Riechmann, van Crüchten, Sablitzky: "The expression pattern of Id4, a novel dominant negative helix-loop-helix protein, is distinct from Id1, Id2 and Id3." in: Nucleic acids research, Vol. 22, Issue 5, pp. 749-55, 1994 (PubMed).

Kadesch: "Consequences of heteromeric interactions among helix-loop-helix proteins." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 4, Issue 1, pp. 49-55, 1993 (PubMed).

Hara, Hall, Peters: "Cdk2-dependent phosphorylation of Id2 modulates activity of E2A-related transcription factors." in: The EMBO journal, Vol. 16, Issue 2, pp. 332-42, 1997 (PubMed).

Cooper, Brady, Bilia et al.: "Expression of the Id family helix-loop-helix regulators during growth and development in the hematopoietic system." in: Blood, Vol. 89, Issue 9, pp. 3155-65, 1997 (PubMed).

Langlands, Yin, Anand et al.: "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors." in: The Journal of biological chemistry, Vol. 272, Issue 32, pp. 19785-93, 1997 (PubMed).

Norton, Atherton: "Coupling of cell growth control and apoptosis functions of Id proteins." in: Molecular and cellular biology, Vol. 18, Issue 4, pp. 2371-81, 1998 (PubMed).

Norton, Deed, Craggs et al.: "Id helix-loop-helix proteins in cell growth and differentiation." in: Trends in cell biology, Vol. 8, Issue 2, pp. 58-65, 1998 (PubMed).

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