SUMO1 Activating Enzyme Subunit 1 (SAE1) (AA 3-247) antibody

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Antigen
Synonyms AOS1, CDGAP, HSPC140, SUA1, UBLE1A, 2400010M20Rik, 2610044L12Rik, AL033372, AW743391, D7Ertd177e, Sua1, Uble1a, Aos1p, Sua1p, aos
Epitope
AA 3-247
(21), (6), (6), (5), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(88), (27), (24), (7), (7), (3)
Host
Rabbit
(72), (10), (6), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(78), (59), (24), (19), (10), (10), (3), (2), (2)
Pubmed 8 references available
Quantity 0.1 mL
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Catalog No. ABIN556523
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Immunogen Recombinant fragment corresponding to a region within amino acids 3 and 247 of SAE1
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Predicted Reactivity Chimpanzee (100%)
Characteristics Cellular Localization: Nucleus
Purification Purified by antigen-affinity chromatography..
Alternative Name SAE1 / AOS1
Background Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1, MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM]
Synonyms: AOS1 antibody, FLJ3091 antibody, HSPC140 antibody, SUA1 antibody, UBLE1A antibody, SAE1 antibody, activator of SUMO1 antibody, sentrin/SUMO-activating protein AOS1 antibody, ubiquitin-like protein SUMO-1 activating enzyme antibody, SUMO-activating enzyme subunit 1 antibody, SUMO-1 activating enzyme E1 N subunit antibody, SUMO-1 activating enzyme subunit 1 antibody, ubiquitin-like 1-activating enzyme E1A antibody, SUMO1 activating enzyme subunit 1 antibody
Molecular Weight 38 kDa
UniProt Q9UBE0
Comment

Positive Controls: A431 , H1299 , mouse brain , Rat2

Restrictions For Research Use only
Format Liquid
Concentration 0.72 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Iavarone, Garg, Lasorella et al.: "The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein." in: Genes & development, Vol. 8, Issue 11, pp. 1270-84, 1994 (PubMed).

Riechmann, van Crüchten, Sablitzky: "The expression pattern of Id4, a novel dominant negative helix-loop-helix protein, is distinct from Id1, Id2 and Id3." in: Nucleic acids research, Vol. 22, Issue 5, pp. 749-55, 1994 (PubMed).

Kadesch: "Consequences of heteromeric interactions among helix-loop-helix proteins." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 4, Issue 1, pp. 49-55, 1993 (PubMed).

Hara, Hall, Peters: "Cdk2-dependent phosphorylation of Id2 modulates activity of E2A-related transcription factors." in: The EMBO journal, Vol. 16, Issue 2, pp. 332-42, 1997 (PubMed).

Cooper, Brady, Bilia et al.: "Expression of the Id family helix-loop-helix regulators during growth and development in the hematopoietic system." in: Blood, Vol. 89, Issue 9, pp. 3155-65, 1997 (PubMed).

Langlands, Yin, Anand et al.: "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors." in: The Journal of biological chemistry, Vol. 272, Issue 32, pp. 19785-93, 1997 (PubMed).

Norton, Atherton: "Coupling of cell growth control and apoptosis functions of Id proteins." in: Molecular and cellular biology, Vol. 18, Issue 4, pp. 2371-81, 1998 (PubMed).

Norton, Deed, Craggs et al.: "Id helix-loop-helix proteins in cell growth and differentiation." in: Trends in cell biology, Vol. 8, Issue 2, pp. 58-65, 1998 (PubMed).

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