N-Myc Downstream Regulated 1 (NDRG1) (AA 1-263) antibody

Details for Product No. ABIN556525
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Antigen
Synonyms
NDRG1, CAP43, CMT4D, DRG-1, DRG1, GC4, HMSNL, NDR1, NMSL, PROXY1, RIT42, RTP, TARG1, TDD5, cap43, cmt4d, drg1, gc4, hmsnl, ndr1, ndrg1, nmsl, proxy1, rit42, rtp, targ1, tdd5, xndrg1, Ndr1, Ndrl, cb775 ... show more
NDRG1, CAP43, CMT4D, DRG-1, DRG1, GC4, HMSNL, NDR1, NMSL, PROXY1, RIT42, RTP, TARG1, TDD5, cap43, cmt4d, drg1, gc4, hmsnl, ndr1, ndrg1, nmsl, proxy1, rit42, rtp, targ1, tdd5, xndrg1, Ndr1, Ndrl, cb775, wu:fb60h02, zgc:63944, NON-RACE SPECIFIC DISEASE RESISTANCE PROTEIN, non race-specific disease resistance 1 show less
Epitope
AA 1-263
(14), (13), (13), (12), (7), (3), (3), (2), (2), (1), (1), (1)
Reactivity
Human
(85), (52), (47), (41), (38), (26), (2), (1), (1), (1), (1)
Host
Rabbit
(73), (12), (9)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2)
Application
Western Blotting (WB)
(64), (30), (27), (27), (18), (4), (2), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 0.1 mL
Shipping to United States (Change)
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Catalog No. ABIN556525
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Immunogen Recombinant fragment corresponding to a region within amino acids 1 and 263 of NDRG1
Isotype IgG
Predicted Reactivity Human (100%)
Characteristics Cellular Localization: Cytoplasm , Nucleus , Cell membrane
Purification Purified by antigen-affinity chromatography..
Alternative Name NDRG1
Background This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. It is necessary for p53-mediated caspase activation and apoptosis. Mutation in this gene has been reported to be causative for hereditary motor and sensory neuropathy-Lom. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq]
Synonyms: CAP43 antibody, CMT4D antibody, DRG1 antibody, GC4 antibody, HMSNL antibody, NDR1 antibody, NMSL antibody, PROXY1 antibody, RIT42 antibody, RTP antibody, TARG1 antibody, TDD5 antibody, NDRG1 antibody, N-myc downstream-regulated gene 1 protein antibody, nickel-specific induction protein Cap43 antibody, protein regulated by oxygen-1 antibody, tunicamycin-responsive protein antibody, protein NDRG1 antibody, differentiation-related gene 1 protein antibody, DRG-1 antibody, reducing agents and tunicamycin-responsive protein antibody, N-myc downstream regulated 1 antibody
Molecular Weight 43 kDa
UniProt Q92597
Research Area Cancer, Angiogenesis, Transcription Factors
Comment

Positive Controls: Target recombinant protein

Restrictions For Research Use only
Format Liquid
Concentration 0.59 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Nevins: "E2F: a link between the Rb tumor suppressor protein and viral oncoproteins." in: Science (New York, N.Y.), Vol. 258, Issue 5081, pp. 424-9, 1992 (PubMed).

Lukas, Petersen, Holm et al.: "Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression." in: Molecular and cellular biology, Vol. 16, Issue 3, pp. 1047-57, 1996 (PubMed).

Magae, Wu, Illenye et al.: "Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members." in: Journal of cell science, Vol. 109 ( Pt 7), Issue 25, pp. 1717-26, 1997 (PubMed).

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