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N-Myc Downstream Regulated 1 (NDRG1) (AA 1-263) antibody

Details for Product No. ABIN556525, Supplier: Login to see
Antigen
  • NDRG1
  • CAP43
  • CMT4D
  • DRG-1
  • DRG1
  • GC4
  • HMSNL
  • NDR1
  • NMSL
  • PROXY1
  • RIT42
  • RTP
  • TARG1
  • TDD5
  • cap43
  • cmt4d
  • drg1
  • gc4
  • hmsnl
  • ndr1
  • ndrg1
  • nmsl
  • proxy1
  • rit42
  • rtp
  • targ1
  • tdd5
  • xndrg1
  • Ndr1
  • Ndrl
  • cb775
  • wu:fb60h02
  • zgc:63944
  • NON-RACE SPECIFIC DISEASE RESISTANCE PROTEIN
  • non race-specific disease resistance 1
Epitope
AA 1-263
28
22
14
6
5
5
4
4
3
2
1
1
1
1
1
1
1
Reactivity
Human
112
41
36
10
4
2
2
2
1
1
1
1
1
Host
Rabbit
86
23
7
2
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
4
3
3
3
3
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
98
48
45
25
15
10
6
5
5
3
1
Supplier
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Immunogen Recombinant fragment corresponding to a region within amino acids 1 and 263 of NDRG1
Isotype IgG
Predicted Reactivity Human (100%)
Characteristics Cellular Localization: Cytoplasm , Nucleus , Cell membrane
Purification Purified by antigen-affinity chromatography..
Alternative Name NDRG1 (NDRG1 Antibody Abstract)
Background This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. It is necessary for p53-mediated caspase activation and apoptosis. Mutation in this gene has been reported to be causative for hereditary motor and sensory neuropathy-Lom. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq]
Synonyms: CAP43 antibody, CMT4D antibody, DRG1 antibody, GC4 antibody, HMSNL antibody, NDR1 antibody, NMSL antibody, PROXY1 antibody, RIT42 antibody, RTP antibody, TARG1 antibody, TDD5 antibody, NDRG1 antibody, N-myc downstream-regulated gene 1 protein antibody, nickel-specific induction protein Cap43 antibody, protein regulated by oxygen-1 antibody, tunicamycin-responsive protein antibody, protein NDRG1 antibody, differentiation-related gene 1 protein antibody, DRG-1 antibody, reducing agents and tunicamycin-responsive protein antibody, N-myc downstream regulated 1 antibody
Molecular Weight 43 kDa
UniProt Q92597
Research Area Cancer, Angiogenesis, Transcription Factors
Pathways
Comment

Positive Controls: Target recombinant protein

Restrictions For Research Use only
Format Liquid
Concentration 0.59 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Magae, Wu, Illenye et al.: "Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members." in: Journal of cell science, Vol. 109 ( Pt 7), Issue 25, pp. 1717-26, 1997 (PubMed).

Lukas, Petersen, Holm et al.: "Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression." in: Molecular and cellular biology, Vol. 16, Issue 3, pp. 1047-57, 1996 (PubMed).

Nevins: "E2F: a link between the Rb tumor suppressor protein and viral oncoproteins." in: Science (New York, N.Y.), Vol. 258, Issue 5081, pp. 424-9, 1992 (PubMed).