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P-Cadherin (AA 55-289) antibody

Details for Product No. ABIN556541, Supplier: Login to see
Antigen
  • CDH3
  • Cadherin-3
  • AI385538
  • Cadp
  • Cdhp
  • P-cadherin
  • Pcad
  • CDHP
  • HJMD
  • PCAD
  • E-Cad
  • E-cadherin
  • EP-cadherin
  • XTCAD-1
  • c-cadherin
  • cadherin-1
  • cdh1
  • cdh1-b
  • cdh3
  • cdhc-A
  • cdhp
  • hjmd
  • l-cam
  • lcam
  • pcad
  • uvo
  • uvomorulin
  • xb-cad
  • xcdh1
  • CDH15
  • K-CAM
Epitope
AA 55-289
22
20
14
14
6
6
4
4
4
3
2
2
2
1
1
1
1
1
1
Reactivity
Human
113
38
24
1
1
1
Host
Rabbit
102
15
2
1
Clonality
Polyclonal
Conjugate
Un-conjugated
7
7
5
4
4
4
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
95
58
56
24
18
11
11
8
5
4
4
2
1
1
Supplier
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Immunogen Recombinant fragment corresponding to a region within amino acids 55 and 289 of P-cadherin
Isotype IgG
Cross-Reactivity Mouse (Murine)
Predicted Reactivity Rat (89%), Bovine (93%)
Characteristics Cellular Localization: Cell membrane
Purification Purified by antigen-affinity chromatography..
Alternative Name Cadherin-3
Background This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy. [provided by RefSeq]
Synonyms: CDHP antibody, HJMD antibody, PCAD antibody, CDH3 antibody, "calcium-dependent adhesion protein, placental antibody", cadherin-3 antibody, "cadherin 3, type 1, P-cadherin (placental) antibody"
Molecular Weight 91 kDa
UniProt P22223
Research Area Extracellular Matrix, Signaling, Cytoskeleton
Pathways
Comment

Positive Controls: 293T , B6 mice E15.5,E18.5 embryo tissue ,

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Supplier Images
Immunohistochemistry (IHC) image for anti-P-Cadherin (AA 55-289) antibody (ABIN556541) anti-P-Cadherin (AA 55-289) antibody
Western Blotting (WB) image for anti-P-Cadherin (AA 55-289) antibody (ABIN556541) anti-P-Cadherin (AA 55-289) antibody (Image 2)
Background publications Chandler, Cohen, MacFarlane: "Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver." in: The Journal of biological chemistry, Vol. 273, Issue 18, pp. 10815-8, 1998 (PubMed).

Duan, Chinnaiyan, Hudson et al.: "ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis." in: The Journal of biological chemistry, Vol. 271, Issue 3, pp. 1621-5, 1996 (PubMed).

Fernandes-Alnemri, Takahashi, Armstrong et al.: "Mch3, a novel human apoptotic cysteine protease highly related to CPP32." in: Cancer research, Vol. 55, Issue 24, pp. 6045-52, 1996 (PubMed).