Glutathione S-Transferase alpha 1 (GSTA1) (AA 1-177) antibody

Details for Product No. ABIN556581
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Antigen
Synonyms GSTA1, gst2, gth1, gsta1-1, GST2, GSTA1-1, GTH1, Gsta1, GSTA3, GST, Gst2-1, OTTMUSG00000031890
Epitope
AA 1-177
(8), (6), (4), (2), (1), (1), (1)
Reactivity
Human
(46), (14), (11), (4), (3), (3)
Host
Rabbit
(39), (28), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (3), (3), (2), (2), (2)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(65), (35), (17), (13), (11), (7), (5), (5), (4)
Pubmed 5 references available
Quantity 0.1 mL
Shipping to United States (Change)
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Catalog No. ABIN556581
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Immunogen Recombinant fragment corresponding to a region within amino acids 1 and 177 of GSTA1
Cross-Reactivity Mouse (Murine)
Predicted Reactivity Monkey (93%)
Characteristics Cellular Localization: Cytoplasm
Purification Purified by antigen-affinity chromatography..
Alternative Name GSTA1
Background Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. [provided by RefSeq]
Synonyms: GST2 antibody, GSTA1-1 antibody, GTH1 antibody, MGC131939 antibody, GSTA1 antibody, "GST, class alpha, 1 antibody", GST HA subunit 1 antibody, glutathione S-aryltransferase A1 antibody, glutathione S-transferase Ha subunit 1 antibody, GST class-alpha member 1 antibody, S-(hydroxyalkyl)glutathione lyase A1 antibody, glutathione S-transferase 2 antibody, glutathione S-transferase A1 antibody, GST-epsilon antibody, glutathione S-alkyltransferase A1 antibody, glutathione S-transferase alpha 1 antibody
Molecular Weight 26 kDa
UniProt P08263
Comment

Positive Controls: HepG2 , mouse liver

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Fernandes-Alnemri, Litwack, Alnemri: "Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family." in: Cancer research, Vol. 55, Issue 13, pp. 2737-42, 1995 (PubMed).

Srinivasula, Fernandes-Alnemri, Zangrilli et al.: "The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32." in: The Journal of biological chemistry, Vol. 271, Issue 43, pp. 27099-106, 1996 (PubMed).

Cohen: "Caspases: the executioners of apoptosis." in: The Biochemical journal, Vol. 326 ( Pt 1), Issue 5693, pp. 1-16, 1997 (PubMed).

Mitamura, Ikawa, Mizuno et al.: "Cytosolic nuclease activated by caspase-3 and inhibited by DFF-45." in: Biochemical and biophysical research communications, Vol. 243, Issue 2, pp. 480-4, 1998 (PubMed).

Cryns, Yuan: "Proteases to die for." in: Genes & development, Vol. 12, Issue 11, pp. 1551-70, 1998 (PubMed).

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