Keratin 4 (KRT4) (AA 89-363) antibody

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Antigen
Synonyms cb59, etID20321.6, krt8, wu:fa91a11, wu:fd19e09, wu:fl23c09, zf-K8, CK-4, CK4, CYK4, K4, Kb4, AW108092, Krt-2.4, Krt2-4
Epitope
AA 89-363
(8), (8), (3), (3), (2), (2), (2), (1), (1), (1)
Reactivity
Human
(80), (26), (18), (18), (13), (5), (3), (1)
Host
Rabbit
(44), (40), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(63), (29), (28), (26), (20), (17), (12), (10), (8), (5), (2)
Pubmed 3 references available
Quantity 0.1 mL
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Catalog No. ABIN556596
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Immunogen Recombinant protein fragment contain a sequence corresponding to a region within amino acids 89 and 363 of Cytokeratin 4
Isotype IgG
Predicted Reactivity Mouse (84%), Rat (85%), Bovine (88%)
Purification Purified by antigen-affinity chromatography..
Alternative Name Cytokeratin 4
Background The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq]
Synonyms: CK4 antibody, CYK4 antibody, FLJ31692 antibody, K4 antibody, KRT4 antibody, "keratin, type II cytoskeletal 4 antibody", type-II keratin Kb4 antibody, cytokeratin 4 antibody, keratin 4 antibody
Molecular Weight 57 kDa
Research Area Signaling, Cytoskeleton, Extracellular Matrix
Comment

Positive Controls: H1299 , HeLa , HepG2 , Molt-4 , Raji

Restrictions For Research Use only
Concentration 0.35 mg/mL
Buffer 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Layfield, Fergusson, Aitken et al.: "Neurofibrillary tangles of Alzheimer's disease brains contain 14-3-3 proteins." in: Neuroscience letters, Vol. 209, Issue 1, pp. 57-60, 1996 (PubMed).

Zha, Harada, Yang et al.: "Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)" in: Cell, Vol. 87, Issue 4, pp. 619-28, 1997 (PubMed).

Skoulakis, Davis: "14-3-3 proteins in neuronal development and function." in: Molecular neurobiology, Vol. 16, Issue 3, pp. 269-84, 1998 (PubMed).

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