Calpain, Small Subunit 1 (CAPNS1) (AA 1-222) antibody

Details for Product No. ABIN558036
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Antigen
Synonyms CAPNS1, MGC84330, 30K, CALPAIN4, CANP, CANPS, CAPN4, CDPS, CSS1, Capn4, Capa-4, Capa4, D7Ertd146e
Epitope
AA 1-222
(6), (3), (2), (2)
Reactivity
Human
(24), (3), (2), (1)
Host
Rabbit
(15), (9)
Clonality
Polyclonal
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(16), (9), (6), (4), (4), (3), (3), (1), (1), (1), (1)
Pubmed 6 references available
Quantity 0.1 mL
Shipping to United States (Change)
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Catalog No. ABIN558036
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Immunogen Recombinant fragment corresponding to a region within amino acids 1 and 222 of Calpain S1
Isotype IgG
Characteristics Cellular Localization: Cytoplasm , Cell membrane
Purification Purified by antigen-affinity chromatography..
Alternative Name CAPNS1
Background Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq]
Synonyms: 30K antibody, CALPAIN4 antibody, CANP antibody, CANPS antibody, CAPN4 antibody, CDPS antibody, CSS1 antibody, CAPNS1 antibody, calpain small subunit 1 antibody, CANP small subunit antibody, calcium-activated neutral proteinase small subunit antibody, calcium-dependent protease small subunit 1 antibody, calpain 4, small subunit (30K) antibody, calcium-dependent protease, small subunit antibody, calpain regulatory subunit antibody, calpain, small polypeptide antibody, calpain, small subunit 1 antibody
Molecular Weight 28 kDa
UniProt P04632
Comment

Positive Controls: 293T

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 1XPBS, 1%BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid multiple freeze-thaw cycles.
Storage -20 °C
Storage Comment Keep as concentrated solution. Aliquot and store at -20°C or below.
Product cited in: Smeal, Binetruy, Mercola et al.: "Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73." in: Molecular and cellular biology, Vol. 12, Issue 8, pp. 3507-13, 1992 (PubMed).

Lamph, Wamsley, Sassone-Corsi et al.: "Induction of proto-oncogene JUN/AP-1 by serum and TPA." in: Nature, Vol. 334, Issue 6183, pp. 629-31, 1988 (PubMed).

Wisdom, Johnson, Moore: "c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms." in: The EMBO journal, Vol. 18, Issue 1, pp. 188-97, 1999 (PubMed).

Behrens, Sibilia, Wagner: "Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation." in: Nature genetics, Vol. 21, Issue 3, pp. 326-9, 1999 (PubMed).

Shaulian, Karin: "AP-1 in cell proliferation and survival." in: Oncogene, Vol. 20, Issue 19, pp. 2390-400, 2001 (PubMed).

Weiss, Bohmann: "Deregulated repression of c-Jun provides a potential link to its role in tumorigenesis." in: Cell cycle (Georgetown, Tex.), Vol. 3, Issue 2, pp. 111-3, 2004 (PubMed).

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