Insulin (INS) antibody

Details for Product No. ABIN558686
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Antigen
Synonyms ins1, xins, ins1-a, Insulin, IDDM2, ILPR, IRDN, MODY10, AA986540, Ins-2, InsII, Mody, Mody4, proinsulin, zgc:109842
Reactivity
Human
(411), (142), (102), (89), (72), (7), (3), (3), (3), (3), (3), (2), (2), (2), (1)
Host
Chicken
(329), (141), (35), (2), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(25), (12), (11), (6), (6), (6), (6), (6), (6), (6), (6), (2), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(284), (138), (83), (82), (82), (60), (52), (35), (18), (17), (13), (9), (7), (6), (5), (4), (3), (3), (1), (1)
Pubmed 5 references available
Quantity 50 µg
Shipping to United States (Change)
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Catalog No. ABIN558686
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Immunogen Recombinant full length protein (Human).
Isotype IgY
Specificity Product recognises insulin (pancreas beta cell secreted hormone).
Cross-Reactivity Mouse (Murine), Cat (Feline), Dog (Canine), Pig (Porcine), Rat (Rattus)
Characteristics Cellular Localization: Secreted
Purification Affinity purified with antigen.
Alternative Name Insulin
Background Insulin is one of the major regulatory hormones of intermediate metabolism throughout the body. The biological actions of this hormone involve integration of carbohydrate, protein, and lipid metabolism. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage,formation of triglycerides and synthesis of proteins and nucleic acids. Immunocytochemical investigations have localized insulin in the B cells of pancreatic islets of Langerhans. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of B cell origin such as insulinoma.
Synonyms: IDDM2, ILPR, IRDN, MODY10
Research Area Neurology, Diabetes, Hormones
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate-buffered saline, no preservatives added
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C
Storage Comment Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below.
Product cited in: Zheng, Flavell: "The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells." in: Cell, Vol. 89, Issue 4, pp. 587-96, 1997 (PubMed).

Anderson, Holzer: "Exercise-induced asthma: is it the right diagnosis in elite athletes?" in: The Journal of allergy and clinical immunology, Vol. 106, Issue 3, pp. 419-28, 2000 (PubMed).

Steenbergen, OudeEngberink, Kramer et al.: "Down-regulation of GATA-3 expression during human papillomavirus-mediated immortalization and cervical carcinogenesis." in: The American journal of pathology, Vol. 160, Issue 6, pp. 1945-51, 2002 (PubMed).

Usary, Llaca, Karaca et al.: "Mutation of GATA3 in human breast tumors." in: Oncogene, Vol. 23, Issue 46, pp. 7669-78, 2004 (PubMed).

Kouros-Mehr, Slorach, Sternlicht et al.: "GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland." in: Cell, Vol. 127, Issue 5, pp. 1041-55, 2006 (PubMed).

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