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Insulin antibody (INS)

Details for Product anti-INS Antibody No. ABIN558686, Supplier: Login to see New
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Antigen
Synonyms ins1, xins, ins1-a, Insulin, IDDM2, ILPR, IRDN, MODY10, AA986540, Ins-2, InsII, Mody, Mody4, proinsulin, zgc:109842
Alternatives
Reactivity
Human
(601), (144), (135), (100), (82), (25), (4), (4), (4), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Host
Chicken
(476), (194), (60), (3), (2)
Clonality
Polyclonal
Conjugate
This Insulin antibody is un-conjugated
(41), (28), (25), (12), (10), (10), (6), (6), (5), (5), (5), (5), (5), (5), (5), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(410), (182), (159), (134), (85), (57), (55), (50), (43), (42), (30), (14), (11), (10), (9), (8), (7), (7), (5), (5), (4), (3), (2), (1), (1)
Pubmed 5 references available
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Quantity 50 μg
Shipping to United States ( )
Immunogen Recombinant full length protein (Human).
Isotype IgY
Specificity Product recognises insulin (pancreas beta cell secreted hormone).
Cross-Reactivity Mouse (Murine), Cat (Feline), Dog (Canine), Pig (Porcine), Rat (Rattus)
Characteristics Cellular Localization: Secreted
Purification Affinity purified with antigen.
Alternative Name Insulin (INS Antibody Abstract)
Background Insulin is one of the major regulatory hormones of intermediate metabolism throughout the body. The biological actions of this hormone involve integration of carbohydrate, protein, and lipid metabolism. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage,formation of triglycerides and synthesis of proteins and nucleic acids. Immunocytochemical investigations have localized insulin in the B cells of pancreatic islets of Langerhans. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of B cell origin such as insulinoma.
Synonyms: IDDM2, ILPR, IRDN, MODY10
Research Area Neurology, Diabetes, Hormones
Pathways NF-kappaB Signaling, RTK Signaling
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate-buffered saline, no preservatives added
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C
Storage Comment Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below.
Supplier Images
ELISA image for anti-Insulin antibody (INS) (ABIN558686) anti-Insulin (INS) antibody
Product cited in: Kouros-Mehr, Slorach, Sternlicht et al.: "GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland." in: Cell, Vol. 127, Issue 5, pp. 1041-55, 2006 (PubMed).

Usary, Llaca, Karaca et al.: "Mutation of GATA3 in human breast tumors." in: Oncogene, Vol. 23, Issue 46, pp. 7669-78, 2004 (PubMed).

Steenbergen, OudeEngberink, Kramer et al.: "Down-regulation of GATA-3 expression during human papillomavirus-mediated immortalization and cervical carcinogenesis." in: The American journal of pathology, Vol. 160, Issue 6, pp. 1945-51, 2002 (PubMed).

Anderson, Holzer: "Exercise-induced asthma: is it the right diagnosis in elite athletes?" in: The Journal of allergy and clinical immunology, Vol. 106, Issue 3, pp. 419-28, 2000 (PubMed).

Zheng, Flavell: "The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells." in: Cell, Vol. 89, Issue 4, pp. 587-96, 1997 (PubMed).

Catalog No. ABIN558686
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