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Alanine Glyoxylate Aminotransferase (AGXT) antibody

Details for Product No. ABIN559027, Supplier: Login to see
Antigen
  • AGT
  • AGT1
  • AGXT1
  • PH1
  • SPAT
  • SPT
  • TLH6
  • Agt1
  • Agxt1
  • Spat
Reactivity
Rat (Rattus)
60
15
8
2
Host
Goat
29
27
16
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
4
4
4
4
Application
ELISA
51
29
9
8
8
8
2
2
1
Supplier
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Immunogen C-DKAKSKVYSRKTK
Isotype IgG
Specificity This antibody is specific for AGXT (rat).
Cross-Reactivity Dog (Canine)
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide..
Alternative Name AGXT / AGT1 (AGXT Antibody Abstract)
Background This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq]
Synonyms: serine pyruva, serine:pyruvate/alanine:glyoxylate aminotransferase, Alanine-glyoxylate aminotransferase (Serine-pyruvate aminotransferase), serine:pyruvate aminotransferase SPT, alanineglyoxylate aminotransferase, AGXT (rat), angiotensin receptor2, Alanineglyoxylate aminotransferase (Serinepyruvate aminotransferase), Agxt, Spat, angiotensin receptor 2
Molecular Weight 43.4 kDa
Pathways
Comment

Positive Controls: The peptide used to product this antibody is available for purchase (Catalog Number:GTX47570-PEP).

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20°C.
Product cited in: Wang, Chao, Chen et al.: "The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB." in: Molecular and cellular biology, Vol. 19, Issue 9, pp. 6195-206, 1999 (PubMed).

Yang, Kozopas, Craig: "The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2." in: The Journal of cell biology, Vol. 128, Issue 6, pp. 1173-84, 1995 (PubMed).

Background publications Gross, McDonnell, Korsmeyer: "BCL-2 family members and the mitochondria in apoptosis." in: Genes & development, Vol. 13, Issue 15, pp. 1899-911, 1999 (PubMed).

Adams, Cory: "The Bcl-2 protein family: arbiters of cell survival." in: Science (New York, N.Y.), Vol. 281, Issue 5381, pp. 1322-6, 1998 (PubMed).

Oltvai, Milliman, Korsmeyer: "Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death." in: Cell, Vol. 74, Issue 4, pp. 609-19, 1993 (PubMed).

Kozopas, Yang, Buchan et al.: "MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 8, pp. 3516-20, 1993 (PubMed).