CHRNA7 (Cholinergic Receptor, Nicotinic, alpha 7, Exons 5-10) and FAM7A (Family with Sequence Similarity 7A, Exons A-E) Fusion (CHRFAM7A) antibody

Details for Product No. ABIN559045
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Antigen
Synonyms CHRNA7, CHRNA7-DR1, D-10
Reactivity
Human
(16), (4), (4), (3), (3), (3), (2), (1)
Host
Goat
(16), (2), (1)
Clonality
Polyclonal
Application
ELISA
(18), (4), (3), (1), (1)
Pubmed 13 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN559045
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Immunogen QKYCIYQHFQFQ
Isotype IgG
Specificity This antibody is specific for CHRFAM7A / CHRNA7-FAM7A.
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide..
Alternative Name CHRFAM7A
Background The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq]
Synonyms: CHRNA7-FAM7A, CHRNA7FAM7A, CHRNA7DR1, alpha 7 neuronal nicotinic acetylcholine receptor-FAM7A hybrid, CHRNA7-DR1, alpha7 neuronal nicotinic acetylcholine receptorFAM7A hybrid, CHRFAM7A / CHRNA7FAM7A, CHRNA7 (cholinergic r, CHRNA7 DR1, CHRNA7 FAM7A
Molecular Weight 46.2 kDa, 35.5 kDa
Research Area Neurology
Comment

Positive Controls: The peptide used to product this antibody is available for purchase (Catalog Number:GTX47588-PEP).

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20°C.
Product cited in: McCormick, Zetter: "Adhesive interactions in angiogenesis and metastasis." in: Pharmacology & therapeutics, Vol. 53, Issue 2, pp. 239-60, 1992 (PubMed).

Grignon, Ro, Ayala et al.: "Primary adenocarcinoma of the urinary bladder. A clinicopathologic analysis of 72 cases." in: Cancer, Vol. 67, Issue 8, pp. 2165-72, 1991 (PubMed).

Zhou, Moore, Smith et al.: "The selectin GMP-140 binds to sialylated, fucosylated lactosaminoglycans on both myeloid and nonmyeloid cells." in: The Journal of cell biology, Vol. 115, Issue 2, pp. 557-64, 1991 (PubMed).

OHara, Corson, Pinkus et al.: "ME1. A monoclonal antibody that distinguishes epithelial-type malignant mesothelioma from pulmonary adenocarcinoma and extrapulmonary malignancies." in: The American journal of pathology, Vol. 136, Issue 2, pp. 421-8, 1990 (PubMed).

Hsu, Huang, Hsu et al.: "Biochemical and ultrastructural study of Leu M1 antigen in Reed-Sternberg cells: comparison with granulocytes and interdigitating reticulum cells." in: Journal of the National Cancer Institute, Vol. 77, Issue 2, pp. 363-70, 1986 (PubMed).

Hanjan, Kearney, Cooper: "A monoclonal antibody (MMA) that identifies a differentiation antigen on human myelomonocytic cells." in: Clinical immunology and immunopathology, Vol. 23, Issue 2, pp. 172-88, 1982 (PubMed).

Paties, Taccagni, Papotti et al.: "Apocrine carcinoma of the skin. A clinicopathologic, immunocytochemical, and ultrastructural study." in: Cancer, Vol. 71, Issue 2, pp. 375-81, 1993 (PubMed).

García Prats, López Carreira, Martínez-González et al.: "Granular cell basal cell carcinoma. Light microscopy, immunohistochemical and ultrastructural study." in: Virchows Archiv. A, Pathological anatomy and histopathology, Vol. 422, Issue 2, pp. 173-7, 1993 (PubMed).

Ma, Zarbo, Frierson et al.: "Comparative immunohistochemical study of primary and metastatic carcinomas of the liver." in: American journal of clinical pathology, Vol. 99, Issue 5, pp. 551-7, 1993 (PubMed).

Torii, Nakayama, Harada et al.: "Expression of the CD15 antigen in hepatocellular carcinoma." in: Cancer, Vol. 71, Issue 12, pp. 3864-7, 1993 (PubMed).

Groves, Allen, Ross et al.: "Expression of selectin ligands by cutaneous squamous cell carcinoma." in: The American journal of pathology, Vol. 143, Issue 4, pp. 1220-5, 1993 (PubMed).

Bevilacqua, Nelson: "Endothelial-leukocyte adhesion molecules in inflammation and metastasis." in: Thrombosis and haemostasis, Vol. 70, Issue 1, pp. 152-4, 1993 (PubMed).

Narita, Funahashi, Satoh et al.: "Association of expression of blood group-related carbohydrate antigens with prognosis in breast cancer." in: Cancer, Vol. 71, Issue 10, pp. 3044-53, 1993 (PubMed).

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