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CHRNA7 (Cholinergic Receptor, Nicotinic, alpha 7, Exons 5-10) and FAM7A (Family with Sequence Similarity 7A, Exons A-E) Fusion (CHRFAM7A) antibody

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  • CHRNA7
  • CHRNA7-DR1
  • D-10
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Isotype IgG
Specificity This antibody is specific for CHRFAM7A / CHRNA7-FAM7A.
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide..
Alternative Name CHRFAM7A (CHRFAM7A Antibody Abstract)
Background The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq]
Synonyms: CHRNA7-FAM7A, CHRNA7FAM7A, CHRNA7DR1, alpha 7 neuronal nicotinic acetylcholine receptor-FAM7A hybrid, CHRNA7-DR1, alpha7 neuronal nicotinic acetylcholine receptorFAM7A hybrid, CHRFAM7A / CHRNA7FAM7A, CHRNA7 (cholinergic r, CHRNA7 DR1, CHRNA7 FAM7A
Molecular Weight 46.2 kDa, 35.5 kDa
Research Area Neurology

Positive Controls: The peptide used to product this antibody is available for purchase (Catalog Number:GTX47588-PEP).

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20°C.
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Background publications Hanjan, Kearney, Cooper: "A monoclonal antibody (MMA) that identifies a differentiation antigen on human myelomonocytic cells." in: Clinical immunology and immunopathology, Vol. 23, Issue 2, pp. 172-88, 1982 (PubMed).