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ATPase, H+ Transporting, Lysosomal 31kDa, V1 Subunit E1 (ATP6V1E1) antibody

Details for Product No. ABIN559600
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Antigen
Synonyms ATP6V1E, zgc:103433, ATP6E, ATP6E2, P31, Vma4, ATP6V0E, ATP6H, M9.2, Vma21, Vma21p, Atp6k, Atp6v0e1, 2410029D23Rik, Atp6e, Atp6e2, Atp6v1e, D6Ertd385e, E2, Atp6v0e, Dsr-1A, dsr-1
Reactivity
Human
(22), (6), (3)
Host
Chicken
(20), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3)
Application
Western Blotting (WB)
(22), (17), (9), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 50 µg
Shipping to United States (Change)
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Catalog No. ABIN559600
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Immunogen Synthetic peptide - human Vacuolar ATP synthase subunit E
Isotype IgY
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Purification Affinity purified with antigen. From polyclonal serum.
Alternative Name ATP6V1E1
Background Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This protein is a component of vacuolar ATPase (V-ATPase). a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting. zymogen activation. receptor-mediated endocytosis. and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A. three B. and two G subunits. as well as a C. D. E. F. and H subunit. The V1 domain contains the ATP catalytic site. This protein is alternate transcriptional splice variants. encoding different V1 domain E subunit isoforms. Pseudogenes for this gene have been found in the genome.
Synonyms: ATP6E, ATP6V1E, Vma4, ATP6V1E1, ATP6E2, P31
Research Area Signaling, Metabolism
Comment

Positive Controls: See Application Note

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate-Buffered Saline containing no preservatives
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C
Storage Comment Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below.
Product cited in: Steck, Pershouse, Jasser et al.: "Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers." in: Nature genetics, Vol. 15, Issue 4, pp. 356-62, 1997 (PubMed).

Suzuki, de la Pompa, Stambolic et al.: "High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice." in: Current biology : CB, Vol. 8, Issue 21, pp. 1169-78, 1998 (PubMed).

Cantley, Neel: "New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 8, pp. 4240-5, 1999 (PubMed).

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