anti-PARP1 antibody (Poly (ADP-Ribose) Polymerase 1) (AA 1-100)

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Antigen
Synonyms
BEST:LD21673, CG17685, CG17696, CG17718, CG40411, D.PARP, Dm.pARTa, Dmel\\CG40411, LD21673.3prime, PARP, PARP-1, PARP1, dPARP, parp, ADPRT, ADPRT 1, ADPRT1, ARTD1, PPOL, pADPRT-1, Adprt, Parp-1, adprt ... show more
BEST:LD21673, CG17685, CG17696, CG17718, CG40411, D.PARP, Dm.pARTa, Dmel\\CG40411, LD21673.3prime, PARP, PARP-1, PARP1, dPARP, parp, ADPRT, ADPRT 1, ADPRT1, ARTD1, PPOL, pADPRT-1, Adprt, Parp-1, adprt1, padprt-1, ppol, 5830444G22Rik, AI893648, Adprp, Adprt1, C80510, parp-1, sPARP-1 show less
Alternatives
Epitope
AA 1-100, partial
(74), (19), (19), (19), (19), (19), (19), (19), (19), (18), (18), (16), (15), (14), (14), (12), (12), (11), (6), (6), (6), (6), (6), (6), (6), (6), (6), (5), (5), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(393), (61), (61), (14), (5), (4), (4), (3), (3), (1), (1), (1), (1), (1)
Host
Mouse
(394), (49), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
This PARP1 antibody is un-conjugated
(26), (25), (24), (24), (23), (23), (2), (2), (2)
Application
ELISA, Immunofluorescence (IF), Western Blotting (WB)
(229), (220), (165), (56), (44), (42), (38), (29), (19), (13), (11), (6), (5), (4), (3), (2), (1), (1)
Pubmed 6 references available
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Quantity 100 μg
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Immunogen PARP1 (AAH37545, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Immunogen sequence: MAESSDKLYR VEYAKSGRAS CKKCSESIPK DSLRMAIMVQ SPMFDGKVPH WYHFSCFWKV GHSIRHPDVE VDGFSELRWD DQQKVKKTAE AGGVTGKGQD
Clone 3G4
Isotype IgG2a kappa
Cross-Reactivity Human
Alternative Name PARP1 (PARP1 Antibody Abstract)
Background Gene: poly (ADP-ribose) polymerase 1
Synonyms: ADPRT, ADPRT1, PARP, PARP-1, PPOL, pADPRT-1
Gene ID 142
Pathways Apoptosis, Caspase Cascade in Apoptosis, DNA Damage Repair
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer In 1x PBS, pH 7.4
Handling Advice Aliquot to avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store at -20 °C or lower. Aliquot to avoid repeated freezing and thawing.
Supplier Images
Immunofluorescence (IF) image for anti-PARP1 antibody (Poly (ADP-Ribose) Polymerase 1) (AA 1-100) (ABIN559798) Immunofluorescence of monoclonal antibody to PARP1 on HeLa cell. [antibody concentrat...
Western Blotting (WB) image for anti-PARP1 antibody (Poly (ADP-Ribose) Polymerase 1) (AA 1-100) (ABIN559798) PARP1 monoclonal antibody (M01), clone 3G4 Western Blot analysis of PARP1 expression ...
ELISA image for anti-PARP1 antibody (Poly (ADP-Ribose) Polymerase 1) (AA 1-100) (ABIN559798) Detection limit for recombinant GST tagged PARP1 is approximately 0.1ng/ml as a captu...
Image no. 4 for anti-PARP1 antibody (Poly (ADP-Ribose) Polymerase 1) (AA 1-100) (ABIN559798) Western Blot detection against Immunogen (36.63 KDa) .
Immunofluorescence (IF) image for anti-PARP1 antibody (Poly (ADP-Ribose) Polymerase 1) (AA 1-100) (ABIN559798) Immunofluorescence of monoclonal antibody to PARP1 on HeLa cell. (antibody concentrat...
Product cited in: Faraoni, Compagnone, Lavorgna et al.: "BRCA1, PARP1 and ?H2AX in acute myeloid leukemia: Role as biomarkers of response to the PARP inhibitor olaparib." in: Biochimica et biophysica acta, Vol. 1852, Issue 3, pp. 462-72, 2015 (PubMed).

Nicolae, Aho, Vlahos et al.: "The ADP-ribosyltransferase PARP10/ARTD10 interacts with proliferating cell nuclear antigen (PCNA) and is required for DNA damage tolerance." in: The Journal of biological chemistry, Vol. 289, Issue 19, pp. 13627-37, 2014 (PubMed).

Shen, Oswald, Phelps et al.: "Regulation of FANCD2 by the mTOR pathway contributes to the resistance of cancer cells to DNA double-strand breaks." in: Cancer research, Vol. 73, Issue 11, pp. 3393-401, 2013 (PubMed).

Pines, Vrouwe, Marteijn et al.: "PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1." in: The Journal of cell biology, Vol. 199, Issue 2, pp. 235-49, 2012 (PubMed).

Luijsterburg, Lindh, Acs et al.: "DDB2 promotes chromatin decondensation at UV-induced DNA damage." in: The Journal of cell biology, Vol. 197, Issue 2, pp. 267-81, 2012 (PubMed).

Crawford, Yang, Mattaini et al.: "The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor." in: The Journal of biological chemistry, Vol. 284, Issue 42, pp. 28660-73, 2009 (PubMed).

Catalog No. ABIN559798
$430.00
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