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CBS antibody (AA 1-100)

CBS Reactivity: Human WB, ELISA, IHC (p), IP, RNAi Host: Mouse Monoclonal 3E1 unconjugated
Catalog No. ABIN7489109
  • Target See all CBS Antibodies
    CBS (Cystathionine-beta-Synthase (CBS))
    Binding Specificity
    • 15
    • 9
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-100
    Reactivity
    • 53
    • 40
    • 11
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 65
    • 8
    Mouse
    Clonality
    • 60
    • 13
    Monoclonal
    Conjugate
    • 38
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CBS antibody is un-conjugated
    Application
    • 55
    • 30
    • 17
    • 15
    • 14
    • 13
    • 13
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), RNA Interference (RNAi)
    Purpose
    Mouse monoclonal antibody raised against a partial recombinant CBS.
    Sequence
    MPSETPQAEV GPTGCPHRSG PHSAKGSLEK GSPEDKEAKE PLWIRPDAPS RCTWQLGRPA SESPHHHTAP AKSPKILPDI LKKIGDTPMV RINKIGKKFG
    Cross-Reactivity
    Human, Rat
    Characteristics
    Antibody Reactive Against Recombinant Protein.
    Immunogen
    CBS (NP_000062, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
    Clone
    3E1
    Isotype
    IgG2a
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    In 1x PBS, pH 7.4
    Handling Advice
    Aliquot to avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Shang, Siow, Isaak, O: "Downregulation of Glutathione Biosynthesis Contributes to Oxidative Stress and Liver Dysfunction in Acute Kidney Injury." in: Oxidative medicine and cellular longevity, Vol. 2016, pp. 9707292, (2016) (PubMed).

    Ohmura, Hishiki, Yamamoto, Nakanishi, Kubo, Tsuchihashi, Tamada, Toue, Kabe, Saya, Suematsu: "Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry." in: Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society, Vol. 46, pp. 102-13, (2015) (PubMed).

    Yuan, Tang, Lu, Zhou, Zhu, Zhou, Zhang, Hu, Xu: "TLR4 upregulates CBS expression through NF-κB activation in a rat model of irritable bowel syndrome with chronic visceral hypersensitivity." in: World journal of gastroenterology, Vol. 21, Issue 28, pp. 8615-28, (2015) (PubMed).

    Yang, Wu, Wood, Whiteman, Bian: "Hydrogen sulfide attenuates opioid dependence by suppression of adenylate cyclase/cAMP pathway." in: Antioxidants & redox signaling, Vol. 20, Issue 1, pp. 31-41, (2014) (PubMed).

    Takano, Peng, Kumar, Luo, Hu, Shimoda, Suematsu, Prabhakar, Semenza: "Hypoxia-inducible factors regulate human and rat cystathionine ?-synthase gene expression." in: The Biochemical journal, Vol. 458, Issue 2, pp. 203-11, (2014) (PubMed).

    Takano, Sarfraz, Gilkes, Chaturvedi, Xiang, Suematsu, Zagzag, Semenza: "Decreased expression of cystathionine ?-synthase promotes glioma tumorigenesis." in: Molecular cancer research : MCR, Vol. 12, Issue 10, pp. 1398-406, (2014) (PubMed).

    Miyamoto, Otsuguro, Yamaguchi, Ito: "Contribution of cysteine aminotransferase and mercaptopyruvate sulfurtransferase to hydrogen sulfide production in peripheral neurons." in: Journal of neurochemistry, Vol. 130, Issue 1, pp. 29-40, (2014) (PubMed).

    Ida, Sawa, Ihara, Tsuchiya, Watanabe, Kumagai, Suematsu, Motohashi, Fujii, Matsunaga, Yamamoto, Ono, Devarie-Baez, Xian, Fukuto, Akaike: "Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 21, pp. 7606-11, (2014) (PubMed).

    Du, Jin, Hong, Li, Wang, Xu, Wang, Zhang, Jia, Liu, Hu: "Downregulation of cystathionine ?-synthase/hydrogen sulfide contributes to rotenone-induced microglia polarization toward M1 type." in: Biochemical and biophysical research communications, Vol. 451, Issue 2, pp. 239-45, (2014) (PubMed).

    Yamamoto, Takano, Ishiwata, Ohmura, Nagahata, Matsuura, Kamata, Sakamoto, Nakanishi, Kubo, Hishiki, Suematsu: "Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway." in: Nature communications, Vol. 5, pp. 3480, (2014) (PubMed).

    Rashid, Heer, Garle, Alexander, Roberts: "Hydrogen sulphide-induced relaxation of porcine peripheral bronchioles." in: British journal of pharmacology, Vol. 168, Issue 8, pp. 1902-10, (2013) (PubMed).

    Hwang, Sarna, Siow, O: "High-fat diet stimulates hepatic cystathionine β-synthase and cystathionine γ-lyase expression." in: Canadian journal of physiology and pharmacology, Vol. 91, Issue 11, pp. 913-9, (2013) (PubMed).

    Yang, Zhao, Ju, Mani, Cao, Puukila, Khaper, Wu, Wang: "Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2." in: Antioxidants & redox signaling, Vol. 18, Issue 15, pp. 1906-19, (2013) (PubMed).

    Shi, Zhang, Xiao, Hu, Xu: "Electroacupuncture suppresses mechanical allodynia and nuclear factor ? B signaling in streptozotocin-induced diabetic rats." in: CNS neuroscience & therapeutics, Vol. 19, Issue 2, pp. 83-90, (2013) (PubMed).

    Liu, Luo, Liang, Xia, Xu, Chen, Chen: "Actions of hydrogen sulfide and ATP-sensitive potassium channels on colonic hypermotility in a rat model of chronic stress." in: PLoS ONE, Vol. 8, Issue 2, pp. e55853, (2013) (PubMed).

    Zhang, Hu, Zhou, Hu, Wang, Chen, Xiao, Huang, Jiang, Xu: "Promoted interaction of nuclear factor-?B with demethylated cystathionine-?-synthetase gene contributes to gastric hypersensitivity in diabetic rats." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 21, pp. 9028-38, (2013) (PubMed).

    Hu, Xu, Miao, Gao, Zhu, Zhou, Xiao, Xu: "Sensitization of sodium channels by cystathionine ?-synthetase activation in colon sensory neurons in adult rats with neonatal maternal deprivation." in: Experimental neurology, Vol. 248, pp. 275-85, (2013) (PubMed).

    Kasparek, Linden, Farrugia, Sarr: "Hydrogen sulfide modulates contractile function in rat jejunum." in: The Journal of surgical research, Vol. 175, Issue 2, pp. 234-42, (2012) (PubMed).

    Guo, Gai, Wang, Jin, Du, Jin: "Characterization of hydrogen sulfide and its synthases, cystathionine ?-synthase and cystathionine ?-lyase, in human prostatic tissue and cells." in: Urology, Vol. 79, Issue 2, pp. 483.e1-5, (2012) (PubMed).

    Dufton, Natividad, Verdu, Wallace: "Hydrogen sulfide and resolution of acute inflammation: A comparative study utilizing a novel fluorescent probe." in: Scientific reports, Vol. 2, pp. 499, (2012) (PubMed).

  • Target
    CBS (Cystathionine-beta-Synthase (CBS))
    Alternative Name
    CBS (CBS Products)
    Synonyms
    hip4 antibody, GB12529 antibody, CBS antibody, DDBDRAFT_0189727 antibody, DDBDRAFT_0191292 antibody, DDB_0189727 antibody, DDB_0191292 antibody, cbs antibody, AI047524 antibody, AI303044 antibody, HIP4 antibody, cb442 antibody, wu:fb37g05 antibody, wu:fm61c07 antibody, wu:fq06c06 antibody, zgc:113704 antibody, cystathionine-beta-synthase L homeolog antibody, cystathionine-beta-synthase antibody, cystathionine beta-synthase antibody, cystathionine beta-synthase CBS antibody, cystathionine beta synthase antibody, cystathionine-beta-synthase S homeolog antibody, cystathionine-beta-synthase b antibody, cbs.L antibody, cbs antibody, Cbs antibody, CBS antibody, CNA06170 antibody, Tb11.02.5400 antibody, cysB antibody, LOC100635325 antibody, cbs.S antibody, cbsb antibody
    Background
    Full Gene Name: cystathionine-beta-synthase
    Synonyms: HIP4
    Gene ID
    875
    NCBI Accession
    NM_000071
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