CTH antibody (AA 1-405)

Catalog No. ABIN560523

Product Details anti-CTH Antibody

Target: CTH (Cystathionase (Cystathionine gamma-Lyase) (CTH))

Binding Specificity: AA 1-405

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CTH antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Mouse monoclonal antibody raised against a full length recombinant CTH.

Sequence: MQEKDASSQG FLPHFQHFAT QAIHVGQDPE QWTSRAVVPP ISLSTTFKQG APGQHSGFEY SRSGNPTRNC LEKAVAALDG AKYCLAFASG LAATVTITHL LKAGDQIICM DDVYGGTNRY FRQVASEFGL KISFVDCSKI KLLEAAITPE TKLVWIETPT NPTQKVIDIE GCAHIVHKHG DIILVVDNTF MSPYFQRPLA LGADISMYSA TKYMNGRSDV VMGLVSVNCE SLHNRLRFLQ NSLGAVPSPI DCYLCNRGLK TLHVRMEKHF KNGMAVAQFL ESNPWVEKVI YPGLPSHPQH ELVKRQCTGC TGMVTFYIKG TLQHAEIFLK NLKLFTLAES LGGFESLAEL PAIMTHASVL KNDRDVLGIS DTLIRLSVGL EDEEDLLEDL DQALKAAHPP SGSHS

Cross-Reactivity: Human, Mouse

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: CTH (AAH15807, 1 a.a. ~ 405 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: S51

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-CTH antibody (ABIN560523)

Ohmura, Hishiki, Yamamoto, Nakanishi, Kubo, Tsuchihashi, Tamada, Toue, Kabe, Saya, Suematsu: "Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry." in: Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society, Vol. 46, pp. 102-13, (2015) (PubMed).

Bucci, Papapetropoulos, Vellecco, Zhou, Zaid, Giannogonas, Cantalupo, Dhayade, Karalis, Wang, Feil, Cirino: "cGMP-dependent protein kinase contributes to hydrogen sulfide-stimulated vasorelaxation." in: PLoS ONE, Vol. 7, Issue 12, pp. e53319, (2013) (PubMed).

Guo, Gai, Wang, Jin, Du, Jin: "Characterization of hydrogen sulfide and its synthases, cystathionine ?-synthase and cystathionine ?-lyase, in human prostatic tissue and cells." in: Urology, Vol. 79, Issue 2, pp. 483.e1-5, (2012) (PubMed).

Streeter, Hart, Badoer: "An investigation of the mechanisms of hydrogen sulfide-induced vasorelaxation in rat middle cerebral arteries." in: Naunyn-Schmiedeberg's archives of pharmacology, Vol. 385, Issue 10, pp. 991-1002, (2012) (PubMed).

Zhang, Yang, Untereiner, Ju, Wu, Wang: "Hydrogen sulfide impairs glucose utilization and increases gluconeogenesis in hepatocytes." in: Endocrinology, Vol. 154, Issue 1, pp. 114-26, (2012) (PubMed).

Zhu, Liu, Liu, Wang, Ni: "Glucocorticoids suppress cystathionine gamma-lyase expression and H2S production in lipopolysaccharide-treated macrophages." in: Cellular and molecular life sciences : CMLS, Vol. 67, Issue 7, pp. 1119-32, (2010) (PubMed).

Siebert, Cantré, Eipel, Vollmar: "H2S contributes to the hepatic arterial buffer response and mediates vasorelaxation of the hepatic artery via activation of K(ATP) channels." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 295, Issue 6, pp. G1266-73, (2008) (PubMed).

Target Details for CTH

Target: CTH (Cystathionase (Cystathionine gamma-Lyase) (CTH))

Alternative Name: CTH (CTH Products)

Background: Full Gene Name: cystathionase (cystathionine gamma-lyase)
Synonyms: MGC9471

Gene ID: 1491

Pathways: ER-Nucleus Signaling, Warburg Effect