anti-DYRK1A antibody (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A) (AA 674-763)

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Antigen
Synonyms DYRK1A, dyrk, dyrk1, hp86, mnb, mnbh, DYRK, DYRK1, HP86, MNB, MNBH, MRD7, 2310043O08Rik, D16Ertd272e, D16Ertd493e, Dyrk, ENSMUSG00000074897, Gm10783, Mnbh, Mp86, mmb, PSK47
Alternatives
Epitope
AA 674-763, partial
(38), (25), (15), (15), (11), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(116), (38), (32), (2), (1), (1), (1)
Host
Mouse
(109), (9), (4), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
This DYRK1A antibody is un-conjugated
(8), (8), (8), (7), (7), (7), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(105), (70), (11), (11), (9), (7), (4), (4), (3), (2), (2)
Pubmed 21 references available
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Quantity 100 μg
Shipping to United States ( )
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Immunogen DYRK1A (NP_001387, 674 a.a. ~ 763 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Immunogen sequence: NQGNQAYQNR PVAANTLDFG QNGAMDVNLT VYSNPRQETG IAGHPTYQFS ANTGPAHYMT EGHLTMRQGA DREESPMTGV CVQQSPVASS
Clone 7D10
Isotype IgG2b kappa
Cross-Reactivity Human
Alternative Name DYRK1A (DYRK1A Antibody Abstract)
Background Full Gene Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Synonyms: DYRK,DYRK1,HP86,MNB,MNBH
Gene ID 1859
NCBI Accession NP_001387, NM_001396
Research Area Neurology, Neurogenesis
Application Notes Optimal working dilution should be determined by the investigator.
Comment

Product Quality tested by: Antibody Reactive Against Recombinant Protein.

Restrictions For Research Use only
Buffer In 1x PBS, pH 7.4
Handling Advice Aliquot to avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store at -20 °C or lower. Aliquot to avoid repeated freezing and thawing.
Supplier Images
Western Blotting (WB) image for anti-DYRK1A antibody (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A) (AA 674-763) (ABIN560675) DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A express...
Western Blotting (WB) image for anti-DYRK1A antibody (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A) (AA 674-763) (ABIN560675) DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A express...
ELISA image for anti-DYRK1A antibody (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A) (AA 674-763) (ABIN560675) Detection limit for recombinant GST tagged DYRK1A is approximately 0.03ng/ml as a cap...
Western Blotting (WB) image for anti-DYRK1A antibody (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A) (AA 674-763) (ABIN560675) DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A express...
Western Blotting (WB) image for anti-DYRK1A antibody (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A) (AA 674-763) (ABIN560675) DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A express...
Western Blotting (WB) image for anti-DYRK1A antibody (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A) (AA 674-763) (ABIN560675) DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A express...
Image no. 7 for anti-DYRK1A antibody (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A) (AA 674-763) (ABIN560675) Western Blot detection against Immunogen (35.53 KDa) .
Product cited in: Stringer, Abeysekera, Dria et al.: "Low dose EGCG treatment beginning in adolescence does not improve cognitive impairment in a Down syndrome mouse model." in: Pharmacology, biochemistry, and behavior, Vol. 138, pp. 70-9, 2015 (PubMed).

Blazek, Abeysekera, Li et al.: "Rescue of the abnormal skeletal phenotype in Ts65Dn Down syndrome mice using genetic and therapeutic modulation of trisomic Dyrk1a." in: Human molecular genetics, Vol. 24, Issue 20, pp. 5687-96, 2015 (PubMed).

Najas, Arranz, Lochhead et al.: "DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome." in: EBioMedicine, Vol. 2, Issue 2, pp. 120-34, 2015 (PubMed).

Thompson, Bhansali, Diebold et al.: "DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3." in: The Journal of experimental medicine, Vol. 212, Issue 6, pp. 953-70, 2015 (PubMed).

Grau, Arató, Fernández-Fernández et al.: "DYRK1A-mediated phosphorylation of GluN2A at Ser(1048) regulates the surface expression and channel activity of GluN1/GluN2A receptors." in: Frontiers in cellular neuroscience, Vol. 8, pp. 331, 2014 (PubMed).

García-Cerro, Martínez, Vidal et al.: "Overexpression of Dyrk1A is implicated in several cognitive, electrophysiological and neuromorphological alterations found in a mouse model of Down syndrome." in: PLoS ONE, Vol. 9, Issue 9, pp. e106572, 2014 (PubMed).

Janel, Sarazin, Corlier et al.: "Plasma DYRK1A as a novel risk factor for Alzheimer's disease." in: Translational psychiatry, Vol. 4, pp. e425, 2014 (PubMed).

Souchet, Latour, Gu et al.: "Molecular rescue of DYRK1A overexpression in cystathionine beta synthase-deficient mouse brain by enriched environment combined with voluntary exercise." in: Journal of molecular neuroscience : MN, Vol. 55, Issue 2, pp. 318-23, 2015 (PubMed).

Rachdi, Kariyawasam, Guez et al.: "Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass." in: Diabetologia, Vol. 57, Issue 5, pp. 960-9, 2014 (PubMed).

Thomazeau, Lassalle, Iafrati et al.: "Prefrontal deficits in a murine model overexpressing the down syndrome candidate gene dyrk1a." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 4, pp. 1138-47, 2014 (PubMed).

Hibaoui, Grad, Letourneau et al.: "Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21." in: EMBO molecular medicine, Vol. 6, Issue 2, pp. 259-77, 2014 (PubMed).

Fant, Durieu, Chicanne et al.: "cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease." in: Molecular pharmacology, Vol. 85, Issue 3, pp. 441-50, 2014 (PubMed).

Pons-Espinal, Martinez de Lagran, Dierssen: "Environmental enrichment rescues DYRK1A activity and hippocampal adult neurogenesis in TgDyrk1A." in: Neurobiology of disease, Vol. 60, pp. 18-31, 2013 (PubMed).

Stefos, Soppa, Dierssen et al.: "NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect." in: PLoS ONE, Vol. 8, Issue 6, pp. e67470, 2013 (PubMed).

Laguna, Barallobre, Marchena et al.: "Triplication of DYRK1A causes retinal structural and functional alterations in Down syndrome." in: Human molecular genetics, Vol. 22, Issue 14, pp. 2775-84, 2013 (PubMed).

Tlili, Jacobs, de Koning et al.: "Hepatocyte-specific Dyrk1a gene transfer rescues plasma apolipoprotein A-I levels and aortic Akt/GSK3 pathways in hyperhomocysteinemic mice." in: Biochimica et biophysica acta, Vol. 1832, Issue 6, pp. 718-28, 2013 (PubMed).

Arque, Casanovas, Dierssen: "Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: possible role in Down syndrome." in: PLoS ONE, Vol. 8, Issue 1, pp. e54285, 2013 (PubMed).

Altafaj, Martín, Ortiz-Abalia et al.: "Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome." in: Neurobiology of disease, Vol. 52, pp. 117-27, 2013 (PubMed).

Spellman, Ahmed, Dubach et al.: "Expression of trisomic proteins in Down syndrome model systems." in: Gene, Vol. 512, Issue 2, pp. 219-25, 2012 (PubMed).

Lilienthal, Kolanowski, Becker: "Development of a sensitive non-radioactive protein kinase assay and its application for detecting DYRK activity in Xenopus laevis oocytes." in: BMC biochemistry, Vol. 11, pp. 20, 2010 (PubMed).

Scott, Berger, McKean: "The role of atmospheric pressure variation in the development of spontaneous pneumothoraces." in: The American review of respiratory disease, Vol. 139, Issue 3, pp. 659-62, 1989 (PubMed).

Catalog No. ABIN560675
$430.00
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