Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (AA 674-763), (partial) antibody

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Antigen
Synonyms DYRK1A, dyrk, dyrk1, hp86, mnb, mnbh, DYRK, DYRK1, HP86, MNB, MNBH, MRD7, 2310043O08Rik, D16Ertd272e, D16Ertd493e, Dyrk, ENSMUSG00000074897, Gm10783, Mnbh, Mp86, mmb, PSK47
Epitope
AA 674-763, partial
(35), (23), (15), (15), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(103), (31), (29), (1), (1), (1)
Host
Mouse
(96), (9), (4), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(8), (8), (8), (7), (7), (7), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(98), (59), (10), (9), (9), (9), (5), (4), (4), (2), (2), (1)
Pubmed 26 references available
Quantity 100 μg
Shipping to United States ( )
Availability Will be delivered in 11 to 12 Business Days
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Immunogen DYRK1A (NP_001387, 674 a.a. ~ 763 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 kDa.
Immunogen sequence: NQGNQAYQNR PVAANTLDFG QNGAMDVNLT VYSNPRQETG IAGHPTYQFS ANTGPAHYMT EGHLTMRQGA DREESPMTGV CVQQSPVASS
Clone 7D10
Isotype IgG2b kappa
Alternative Name DYRK1A (DYRK1A Antibody Abstract)
Background Gene: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Synonyms: DYRK, DYRK1, HP86, MNB, MNBH
Gene ID 1859
NCBI Accession NP_001387, NM_001396
Research Area Neurology, Neurogenesis
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer In 1x PBS, pH 7.4
Handling Advice Aliquot to avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Supplier Images
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (AA 674-763), (partial) antibody DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A express...
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (AA 674-763), (partial) antibody (2) DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A express...
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (AA 674-763), (partial) antibody (3) Detection limit for recombinant GST tagged DYRK1A is approximately 0.03 ng/mL as a ca...
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (AA 674-763), (partial) antibody (4) DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A express...
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (AA 674-763), (partial) antibody (5) DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A express...
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (AA 674-763), (partial) antibody (6) DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A express...
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (AA 674-763), (partial) antibody (7) Western Blot detection against Immunogen (35.53 KDa) .
Product cited in: Janel, Sarazin, Corlier et al.: "Plasma DYRK1A as a novel risk factor for Alzheimer's disease." in: Translational psychiatry, Vol. 4, pp. e425, 2014 (PubMed).

Souchet, Latour, Gu et al.: "Molecular rescue of DYRK1A overexpression in cystathionine beta synthase-deficient mouse brain by enriched environment combined with voluntary exercise." in: Journal of molecular neuroscience : MN, Vol. 55, Issue 2, pp. 318-23, 2015 (PubMed).

Rachdi, Kariyawasam, Guez et al.: "Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass." in: Diabetologia, Vol. 57, Issue 5, pp. 960-9, 2014 (PubMed).

Thomazeau, Lassalle, Iafrati et al.: "Prefrontal deficits in a murine model overexpressing the down syndrome candidate gene dyrk1a." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 4, pp. 1138-47, 2014 (PubMed).

Fant, Durieu, Chicanne et al.: "cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease." in: Molecular pharmacology, Vol. 85, Issue 3, pp. 441-50, 2014 (PubMed).

Pons-Espinal, Martinez de Lagran, Dierssen: "Environmental enrichment rescues DYRK1A activity and hippocampal adult neurogenesis in TgDyrk1A." in: Neurobiology of disease, Vol. 60, pp. 18-31, 2013 (PubMed).

Stefos, Soppa, Dierssen et al.: "NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect." in: PLoS ONE, Vol. 8, Issue 6, pp. e67470, 2013 (PubMed).

Laguna, Barallobre, Marchena et al.: "Triplication of DYRK1A causes retinal structural and functional alterations in Down syndrome." in: Human molecular genetics, Vol. 22, Issue 14, pp. 2775-84, 2013 (PubMed).

Tlili, Jacobs, de Koning et al.: "Hepatocyte-specific Dyrk1a gene transfer rescues plasma apolipoprotein A-I levels and aortic Akt/GSK3 pathways in hyperhomocysteinemic mice." in: Biochimica et biophysica acta, Vol. 1832, Issue 6, pp. 718-28, 2013 (PubMed).

Arque, Casanovas, Dierssen: "Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: possible role in Down syndrome." in: PLoS ONE, Vol. 8, Issue 1, pp. e54285, 2013 (PubMed).

Spellman, Ahmed, Dubach et al.: "Expression of trisomic proteins in Down syndrome model systems." in: Gene, Vol. 512, Issue 2, pp. 219-25, 2012 (PubMed).

Abekhoukh, Planque, Ripoll et al.: "Dyrk1A, a serine/threonine kinase, is involved in ERK and Akt activation in the brain of hyperhomocysteinemic mice." in: Molecular neurobiology, Vol. 47, Issue 1, pp. 105-16, 2013 (PubMed).

Planque, Dairou, Noll et al.: "Mice deficient in cystathionine beta synthase display increased Dyrk1A and SAHH activities in brain." in: Journal of molecular neuroscience : MN, Vol. 50, Issue 1, pp. 1-6, 2013 (PubMed).

Malinge, Bliss-Moreau, Kirsammer et al.: "Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome." in: The Journal of clinical investigation, Vol. 122, Issue 3, pp. 948-62, 2012 (PubMed).

Guedj, Pereira, Najas et al.: "DYRK1A: a master regulatory protein controlling brain growth." in: Neurobiology of disease, Vol. 46, Issue 1, pp. 190-203, 2012 (PubMed).

Park, Sung, Park et al.: "Dyrk1A negatively regulates the actin cytoskeleton through threonine phosphorylation of N-WASP." in: Journal of cell science, Vol. 125, Issue Pt 1, pp. 67-80, 2012 (PubMed).

Ahmed, Sturgeon, Ellison et al.: "Loss of correlations among proteins in brains of the Ts65Dn mouse model of down syndrome." in: Journal of proteome research, Vol. 11, Issue 2, pp. 1251-63, 2012 (PubMed).

Sheppard, Plattner, Rubin et al.: "Altered regulation of tau phosphorylation in a mouse model of down syndrome aging." in: Neurobiology of aging, Vol. 33, Issue 4, pp. 828.e31-44, 2012 (PubMed).

Toiber, Azkona, Ben-Ari et al.: "Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations." in: Neurobiology of disease, Vol. 40, Issue 1, pp. 348-59, 2010 (PubMed).

Lilienthal, Kolanowski, Becker: "Development of a sensitive non-radioactive protein kinase assay and its application for detecting DYRK activity in Xenopus laevis oocytes." in: BMC biochemistry, Vol. 11, pp. 20, 2010 (PubMed).

Noll, Planque, Ripoll et al.: "DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase." in: PLoS ONE, Vol. 4, Issue 10, pp. e7540, 2009 (PubMed).

Background publications García-Cerro, Martínez, Vidal et al.: "Overexpression of Dyrk1A is implicated in several cognitive, electrophysiological and neuromorphological alterations found in a mouse model of Down syndrome." in: PLoS ONE, Vol. 9, Issue 9, pp. e106572, 2014 (PubMed).

Hibaoui, Grad, Letourneau et al.: "Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21." in: EMBO molecular medicine, Vol. 6, Issue 2, pp. 259-77, 2014 (PubMed).

Altafaj, Martín, Ortiz-Abalia et al.: "Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome." in: Neurobiology of disease, Vol. 52, pp. 117-27, 2013 (PubMed).

Guo, Kesimer, Tolun et al.: "The NAD(+)-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status." in: Scientific reports, Vol. 2, pp. 640, 2012 (PubMed).

Raaf, Noll, Cherifi et al.: "Hyperhomocysteinemia-induced Dyrk1a downregulation results in cardiomyocyte hypertrophy in rats." in: International journal of cardiology, Vol. 145, Issue 2, pp. 306-7, 2010 (PubMed).

Validation Images
Catalog No. ABIN560675
330.00 $
Plus shipping costs $45.00 and $22.00 dry ice
Quantity
Price
100 μg
330.00 $

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