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GCLC antibody (AA 528-637)

GCLC Reactivity: Human WB, ELISA, IF Host: Mouse Monoclonal 3H1 unconjugated
Catalog No. ABIN561050
  • Target See all GCLC Antibodies
    GCLC (Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC))
    Binding Specificity
    • 10
    • 9
    • 8
    • 7
    • 7
    • 6
    • 6
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 528-637
    Reactivity
    • 68
    • 22
    • 20
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 69
    • 3
    Mouse
    Clonality
    • 60
    • 12
    Monoclonal
    Conjugate
    • 36
    • 6
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This GCLC antibody is un-conjugated
    Application
    • 54
    • 35
    • 28
    • 16
    • 15
    • 9
    • 9
    • 5
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF)
    Purpose
    Mouse monoclonal antibody raised against a partial recombinant GCLC.
    Sequence
    EGVFPGLIPI LNSYLENMEV DVDTRCSILN YLKLIKKRAS GELMTVARWM REFIANHPDY KQDSVITDEM NYSLILKCNQ IANELCECPE LLGSAFRKVK YSGSKTDSSN
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Antibody Reactive Against Recombinant Protein.
    Immunogen
    GCLC (NP_001489, 528 a.a. ~ 637 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
    Clone
    3H1
    Isotype
    IgG1
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    In 1x PBS, pH 7.4
    Handling Advice
    Aliquot to avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Sugiyama, Ebinuma, Nakamoto, Sakasegawa, Murakami, Chu, Usui, Ishibashi, Wakayama, Taniki, Murata, Saito, Fukasawa, Saito, Yamagishi, Wakita, Takaku, Hibi, Saito, Kanai: "Prominent steatosis with hypermetabolism of the cell line permissive for years of infection with hepatitis C virus." in: PLoS ONE, Vol. 9, Issue 4, pp. e94460, (2014) (PubMed).

    Venè, Cardinali, Arena, Ferrari, Benelli, Minghelli, Poggi, Noonan, Albini, Tosetti: "Glycogen synthase kinase 3 regulates cell death and survival signaling in tumor cells under redox stress." in: Neoplasia (New York, N.Y.), Vol. 16, Issue 9, pp. 710-22, (2014) (PubMed).

    Li, Gunter, Fukagawa: "Differential activation of the inflammasome in THP-1 cells exposed to chrysotile asbestos and Libby "six-mix" amphiboles and subsequent activation of BEAS-2B cells." in: Cytokine, Vol. 60, Issue 3, pp. 718-30, (2012) (PubMed).

    Fan, Liu, Hao, Wang, Robinson, Monnier: "The LEGSKO mouse: a mouse model of age-related nuclear cataract based on genetic suppression of lens glutathione synthesis." in: PLoS ONE, Vol. 7, Issue 11, pp. e50832, (2012) (PubMed).

    Abel, Bubel, Simper, Powell, McClellan, Andreeff, MacLeod, DiGiovanni: "Protection against 2-chloroethyl ethyl sulfide (CEES)-induced cytotoxicity in human keratinocytes by an inducer of the glutathione detoxification pathway." in: Toxicology and applied pharmacology, Vol. 255, Issue 2, pp. 176-83, (2011) (PubMed).

    Hardwick, Fisher, Canet, Lake, Cherrington: "Diversity in antioxidant response enzymes in progressive stages of human nonalcoholic fatty liver disease." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 38, Issue 12, pp. 2293-301, (2010) (PubMed).

  • Target
    GCLC (Glutamate-Cysteine Ligase, Catalytic Subunit (GCLC))
    Alternative Name
    GCLC (GCLC Products)
    Synonyms
    GCLC antibody, gclc antibody, MGC146287 antibody, 2259 antibody, CG2259 antibody, DmGCLC antibody, DmGCS antibody, DmGCSh antibody, Dmel\\CG2259 antibody, GCL antibody, GCLc antibody, GCSh antibody, Gcs antibody, Gcsh antibody, DDBDRAFT_0186120 antibody, DDBDRAFT_0231403 antibody, DDB_0186120 antibody, DDB_0231403 antibody, GCS antibody, GLCL antibody, GLCLC antibody, D9Wsu168e antibody, GLCL-H antibody, Ggcs-hs antibody, Glclc antibody, cb1049 antibody, fe36e11 antibody, wu:fe36e11 antibody, glutamate-cysteine ligase catalytic subunit antibody, glutamate-cysteine ligase, catalytic subunit antibody, Glutamate-cysteine ligase catalytic subunit antibody, gamma glutamylcysteine synthetase antibody, glutamate-cysteine ligase, catalytic subunit L homeolog antibody, glutamate-cysteine ligase, catalytic subunit S homeolog antibody, gamma-glutamylcysteine synthetase antibody, GCLC antibody, gclc antibody, Gclc antibody, LbGCS antibody, gcsA antibody, gclc.L antibody, gclc.S antibody, GSH1 antibody
    Background
    Full Gene Name: glutamate-cysteine ligase, catalytic subunit
    Synonyms: GCS,GLCL,GLCLC
    Gene ID
    2729
    NCBI Accession
    NM_001498
    Pathways
    Cell RedoxHomeostasis
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