HLA-DMB antibody (AA 22-129)

Catalog No. ABIN561269

Product Details anti-HLA-DMB Antibody

Target: HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))

Binding Specificity: AA 22-129

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HLA-DMB antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purpose: Mouse monoclonal antibody raised against a partial recombinant HLA-DMB.

Sequence: VAHVESTCLL DDAGTPKDFT YCISFNKDLL TCWDPEENKM APCEFGVLNS LANVLSQHLN QKDTLMQRLR NGLQNCATHT QPFWGSLTNR TRPPSVQVAK TTPFNTRE

Cross-Reactivity: Human

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: HLA-DMB (NP_002109, 22 a.a. ~ 129 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: 6B3

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-HLA-DMB antibody (ABIN561269)

Callahan, Nagymanyoki, Bonome, Johnson, Litkouhi, Sullivan, Hirsch, Matulonis, Liu, Birrer, Berkowitz, Mok: "Increased HLA-DMB expression in the tumor epithelium is associated with increased CTL infiltration and improved prognosis in advanced-stage serous ovarian cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 23, pp. 7667-73, (2008) (PubMed).

Klee, Finlay, McDonald, Attewell, Hebrink, Dyer, Love, Vasmatzis, Li, Beechem, Klee: "Bioinformatics methods for prioritizing serum biomarker candidates." in: Clinical chemistry, Vol. 52, Issue 11, pp. 2162-4, (2007) (PubMed).

Target Details for HLA-DMB

Target: HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))

Alternative Name: HLA-DMB (HLA-DMB Products)

Synonyms: RING7 antibody, D6S221E antibody, RT1.DMb antibody, RT1.Mb antibody, MHC-DMB antibody, major histocompatibility complex, class II, DM beta antibody, RT1 class II, locus DMb antibody, HLA-DMB antibody, RT1-DMb antibody, PATR-DMB antibody

Background: Full Gene Name: major histocompatibility complex, class II, DM beta
Synonyms: D6S221E,RING7

Gene ID: 3109

NCBI Accession: NM_002118

Pathways: Cancer Immune Checkpoints