HSD17B3 antibody (AA 29-119)

Catalog No. ABIN561372

Product Details anti-HSD17B3 Antibody

Target: HSD17B3 (Hydroxysteroid (17-Beta) Dehydrogenase 3 (HSD17B3))

Binding Specificity: AA 29-119

Reactivity: Human

Host: Mouse

Clonality: Polyclonal

Conjugate: This HSD17B3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purpose: Mouse polyclonal antibody raised against a partial recombinant HSD17B3.

Sequence: RCVLLNYWKV LPKSFLRSMG QWAVITGAGD GIGKAYSFEL AKRGLNVVLI SRTLEKLEAI ATEIERTTGR SVKIIQADFT KDDIYEHIKE K

Cross-Reactivity: Human, Mouse

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: HSD17B3 (NP_000188, 29 a.a. ~ 119 a.a) partial recombinant protein with GST tag.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 50 % glycerol

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-HSD17B3 antibody (ABIN561372)

Fokidis, Yieng Chin, Ho, Adomat, Soma, Fazli, Nip, Cox, Krystal, Zoubeidi, Tomlinson Guns: "A low carbohydrate, high protein diet suppresses intratumoral androgen synthesis and slows castration-resistant prostate tumor growth in mice." in: The Journal of steroid biochemistry and molecular biology, Vol. 150, pp. 35-45, (2015) (PubMed).

Ming, Pham, Deb, Chin, Kharmate, Adomat, Beheshti, Locke, Guns: "Pomegranate extracts impact the androgen biosynthesis pathways in prostate cancer models in vitro and in vivo." in: The Journal of steroid biochemistry and molecular biology, Vol. 143, pp. 19-28, (2014) (PubMed).

Locke, Guns, Lubik, Adomat, Hendy, Wood, Ettinger, Gleave, Nelson: "Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer." in: Cancer research, Vol. 68, Issue 15, pp. 6407-15, (2008) (PubMed).

Target Details for HSD17B3

Target: HSD17B3 (Hydroxysteroid (17-Beta) Dehydrogenase 3 (HSD17B3))

Alternative Name: HSD17B3 (HSD17B3 Products)

Synonyms: EDH17B3 antibody, SDR12C2 antibody, hydroxysteroid (17-beta) dehydrogenase 3 antibody, hydroxysteroid 17-beta dehydrogenase 3 antibody, Hsd17b3 antibody, HSD17B3 antibody

Background: Full Gene Name: hydroxysteroid (17-beta) dehydrogenase 3
Synonyms: EDH17B3,SDR12C2

Gene ID: 3293

NCBI Accession: NM_000197

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis