ISL1 antibody (AA 63-159)

Catalog No. ABIN561536

Product Details anti-ISL1 Antibody

Target: ISL1 (ISL LIM Homeobox 1 (ISL1))

Binding Specificity: AA 63-159

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ISL1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Purpose: Mouse monoclonal antibody raised against a partial recombinant ISL1.

Sequence: YCKRDYIRLY GIKCAKCSIG FSKNDFVMRA RSKVYHIECF RCVACSRQLI PGDEFALRED GLFCRADHDV VERASLGAGD PLSPLHPARP LQMAAEP

Cross-Reactivity: Human, Rat

Characteristics: Antibody Reactive Against Recombinant Protein.

Immunogen: ISL1 (NP_002193, 63 a.a. ~ 159 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: 2E7

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: In 1x PBS, pH 7.4

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

References for anti-ISL1 antibody (ABIN561536)

Tian, Wang, Lu, Chen, Ma, Jia, Zhou: "Cross-talk of SFRP4, integrin α1β1, and Notch1 inhibits cardiac differentiation of P19CL6 cells." in: Cellular signalling, Vol. 28, Issue 11, pp. 1806-15, (2016) (PubMed).

Zhang, Yang, Wang, Guo, Jia, Ma, Zhou: "A positive feedback regulation of ISL-1 in DLBCL but not in pancreatic ?-cells." in: Biochemical and biophysical research communications, Vol. 449, Issue 3, pp. 295-300, (2014) (PubMed).

Zhang, Yang, Jia, Liu, Guo, Lu, Chen, Ma, Wang, Zhou: "ISL-1 is overexpressed in non-Hodgkin lymphoma and promotes lymphoma cell proliferation by forming a p-STAT3/p-c-Jun/ISL-1 complex." in: Molecular cancer, Vol. 13, pp. 181, (2014) (PubMed).

Li, Jia, Wang, Wang, Zhang, Chen, Ma, Zhou: "Interaction of Wnt/?-catenin and notch signaling in the early stage of cardiac differentiation of P19CL6 cells." in: Journal of cellular biochemistry, Vol. 113, Issue 2, pp. 629-39, (2012) (PubMed).

Guo, Wang, Zhang, Liu, Chen, Ma, Zhou: "ISL1 promotes pancreatic islet cell proliferation." in: PLoS ONE, Vol. 6, Issue 8, pp. e22387, (2011) (PubMed).

Target Details for ISL1

Target: ISL1 (ISL LIM Homeobox 1 (ISL1))

Alternative Name: ISL1 (ISL1 Products)

Synonyms: Xisl-1 antibody, Xislet-1 antibody, islet1 antibody, ISLET-1 antibody, ISLET1 antibody, Isl-1 antibody, islet-1 antibody, isl-1=homeobox antibody, Islet-1 antibody, ISL LIM homeobox 1 S homeolog antibody, ISL LIM homeobox 1 antibody, ISL1 transcription factor, LIM/homeodomain antibody, isl1.S antibody, ISL1 antibody, Isl1 antibody, isl1 antibody

Background: Full Gene Name: ISL LIM homeobox 1
Synonyms: Isl-1

Gene ID: 3670

NCBI Accession: NM_002202

Pathways: Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding