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Pleiotrophin antibody (AA 45-154)

PTN Reactivity: Human WB, ELISA, IHC (p) Host: Mouse Monoclonal 5C3 unconjugated
Catalog No. ABIN562528
  • Target See all Pleiotrophin (PTN) Antibodies
    Pleiotrophin (PTN)
    Binding Specificity
    • 14
    • 10
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 45-154
    Reactivity
    • 51
    • 29
    • 28
    • 7
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    Human
    Host
    • 69
    • 5
    • 2
    • 2
    Mouse
    Clonality
    • 72
    • 6
    Monoclonal
    Conjugate
    • 35
    • 12
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This Pleiotrophin antibody is un-conjugated
    Application
    • 45
    • 26
    • 26
    • 25
    • 21
    • 15
    • 8
    • 7
    • 6
    • 5
    • 2
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purpose
    Mouse monoclonal antibody raised against a partial recombinant PTN.
    Sequence
    SDCGEWQWSV CVPTSGDCGL GTREGTRTGA ECKQTMKTQR CKIPCNWKKQ FGAECKYQFQ AWGECDLNTA LKTRTGSLKR ALHNAECQKT VTISKPCGKL TKPKPQAESK
    Cross-Reactivity
    Human
    Characteristics
    Antibody Reactive Against Recombinant Protein.
    Immunogen
    PTN (NP_002816, 45 a.a. ~ 154 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
    Clone
    5C3
    Isotype
    IgG1
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    In 1x PBS, pH 7.4
    Handling Advice
    Aliquot to avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • He, Boulant, Stanifer, Guo, Nießen, Chen, Felix, Bergmann, Strobel, Schimmack: "The link between menin and pleiotrophin in the tumor biology of pancreatic neuroendocrine neoplasms." in: Cancer science, Vol. 113, Issue 5, pp. 1575-1586, (2022) (PubMed).

    Koutsioumpa, Polytarchou, Courty, Zhang, Kieffer, Mikelis, Skandalis, Hellman, Iliopoulos, Papadimitriou: "Interplay between ?v?3 integrin and nucleolin regulates human endothelial and glioma cell migration." in: The Journal of biological chemistry, Vol. 288, Issue 1, pp. 343-54, (2013) (PubMed).

    Kaspiris, Mikelis, Heroult, Khaldi, Grivas, Kouvaras, Dangas, Vasiliadis, Lioté, Courty, Papadimitriou: "Expression of the growth factor pleiotrophin and its receptor protein tyrosine phosphatase beta/zeta in the serum, cartilage and subchondral bone of patients with osteoarthritis." in: Joint, bone, spine : revue du rhumatisme, Vol. 80, Issue 4, pp. 407-13, (2013) (PubMed).

    Miao, Ding, Zhang, Xiao, Qi, Luo, Di, Tao, Fang: "Pleiotrophin promotes microglia proliferation and secretion of neurotrophic factors by activating extracellular signal-regulated kinase 1/2 pathway." in: Neuroscience research, Vol. 74, Issue 3-4, pp. 269-76, (2012) (PubMed).

    Tsirmoula, Dimas, Hatziapostolou, Lamprou, Ravazoula, Papadimitriou: "Implications of pleiotrophin in human PC3 prostate cancer cell growth in vivo." in: Cancer science, Vol. 103, Issue 10, pp. 1826-32, (2012) (PubMed).

    Mikelis, Lamprou, Koutsioumpa, Koutsioubas, Spyranti, Zompra, Spiliopoulos, Vradis, Katsoris, Spyroulias, Cordopatis, Courty, Papadimitriou: "A peptide corresponding to the C-terminal region of pleiotrophin inhibits angiogenesis in vivo and in vitro." in: Journal of cellular biochemistry, Vol. 112, Issue 6, pp. 1532-43, (2011) (PubMed).

    Koutsioumpa, Hatziapostolou, Mikelis, Koolwijk, Papadimitriou: "Aprotinin stimulates angiogenesis and human endothelial cell migration through the growth factor pleiotrophin and its receptor protein tyrosine phosphatase beta/zeta." in: European journal of pharmacology, Vol. 602, Issue 2-3, pp. 245-9, (2009) (PubMed).

    Mikelis, Sfaelou, Koutsioumpa, Kieffer, Papadimitriou: "Integrin alpha(v)beta(3) is a pleiotrophin receptor required for pleiotrophin-induced endothelial cell migration through receptor protein tyrosine phosphatase beta/zeta." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 23, Issue 5, pp. 1459-69, (2009) (PubMed).

  • Target
    Pleiotrophin (PTN)
    Alternative Name
    PTN (PTN Products)
    Synonyms
    zHBNF antibody, zgc:111787 antibody, harp antibody, hbnf antibody, X-PTF antibody, hbgf8 antibody, negf1 antibody, ptn antibody, PTN antibody, HARP antibody, HBGF8 antibody, HBNF antibody, NEGF1 antibody, PTN-A antibody, HB-GAM antibody, HBBM antibody, HBGF-8 antibody, OSF-1 antibody, HBBN antibody, OSF antibody, Osf-1 antibody, Osf1 antibody, Hbnf antibody, pleiotrophin antibody, pleiotrophin L homeolog antibody, ptn antibody, PTN antibody, ptn.L antibody, Ptn antibody
    Background
    Full Gene Name: pleiotrophin
    Synonyms: HARP,HBGF8,HBNF,NEGF1
    Gene ID
    5764
    NCBI Accession
    NM_002825
    Pathways
    RTK Signaling
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