TRIB2 antibody (AA 254-343)
TRIB2
Reactivity: Human
WB, ELISA, IHC (p), RNAi
Host: Mouse
Monoclonal
1B1
unconjugated
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Target
See all TRIB2 Antibodies
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TRIB2
(Tribbles Pseudokinase 2 (TRIB2))
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Binding Specificity
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AA 254-343
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Reactivity
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Human
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Host
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Mouse
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Clonality
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Monoclonal
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Conjugate
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This TRIB2 antibody is un-conjugated
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Application
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Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), RNA Interference (RNAi)
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Purpose
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Mouse monoclonal antibody raised against a partial recombinant TRIB2.
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Sequence
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FHDIEPSSLF SKIRRGQFNI PETLSPKAKC LIRSILRREP SERLTSQEIL DHPWFSTDFS VSNSAYGAKE VSDQLVPDVN MEENLDPFFN
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Cross-Reactivity
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Human
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Characteristics
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Antibody Reactive Against Recombinant Protein.
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Immunogen
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TRIB2 (NP_067675, 254 a.a. ~ 343 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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Clone
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1B1
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Isotype
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IgG2b
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Application Notes
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Optimal working dilution should be determined by the investigator.
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Restrictions
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For Research Use only
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Buffer
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In 1x PBS, pH 7.4
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Handling Advice
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Aliquot to avoid repeated freezing and thawing.
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Storage
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-20 °C
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Storage Comment
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Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Xu, Tong, Huang, Zhang, Qiao, Weng, Liu, Wang, Sun: "TRIB2 inhibits Wnt/?-Catenin/TCF4 signaling through its associated ubiquitin E3 ligases, ?-TrCP, COP1 and Smurf1, in liver cancer cells." in: FEBS letters, Vol. 588, Issue 23, pp. 4334-41, (2014) (PubMed).
Wang, Zhang, Weng, Qiao, Ma, Xiao, Yu, Pan, Sun et al.: "Impaired phosphorylation and ubiquitination by p70 S6 kinase (p70S6K) and Smad ubiquitination regulatory factor 1 (Smurf1) promote tribbles homolog 2 (TRIB2) stability and carcinogenic property in ..." in: The Journal of biological chemistry, Vol. 288, Issue 47, pp. 33667-81, (2013) (PubMed).
Qiao, Zhang, Wang: "Ubiquitin E3 ligase SCF(?-TRCP) regulates TRIB2 stability in liver cancer cells." in: Biochemical and biophysical research communications, Vol. 441, Issue 3, pp. 555-9, (2013) (PubMed).
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Target
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TRIB2
(Tribbles Pseudokinase 2 (TRIB2))
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Alternative Name
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TRIB2 (TRIB2 Products)
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Synonyms
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TRIB2 antibody, Trb2 antibody, Xtrbl antibody, gs3955 antibody, c5fw antibody, trb2 antibody, xtrb2 antibody, TRB2 antibody, C5FW antibody, GS3955 antibody, TRB-2 antibody, AW319517 antibody, RGD1564451 antibody, tribbles pseudokinase 2 antibody, tribbles pseudokinase 2 S homeolog antibody, TRIB2 antibody, trib2 antibody, trib2.S antibody, Trib2 antibody
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Background
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Full Gene Name: tribbles homolog 2 (Drosophila)
Synonyms: C5FW,GS3955,TRB2
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Gene ID
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28951
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NCBI Accession
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NM_021643
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