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MMP14 antibody (Matrix Metallopeptidase 14 (Membrane-inserted))

Details for Product anti-MMP14 Antibody No. ABIN567587, Supplier: Log in to see
Antigen
  • MMP-14
  • mmp-x1
  • mt1-mmp
  • mtmmp1
  • MMP-X1
  • MT-MMP
  • MT-MMP 1
  • MT1-MMP
  • MT1MMP
  • MTMMP1
  • AI325305
  • MT-MMP-1
  • sabe
  • Mt1-mmp
  • MMP1
  • matrix metallopeptidase 14 (membrane-inserted)
  • mmp14
  • MMP14
  • Mmp14
Reactivity
Human
241
61
58
13
11
8
6
6
5
4
3
3
3
1
1
1
1
Host
Mouse
163
67
12
2
Clonality (Clone)
Monoclonal ()
Conjugate
This MMP14 antibody is un-conjugated
10
10
10
8
6
6
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
203
117
88
54
38
16
12
11
6
4
1
1
1
1
Options
Supplier
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Available images

Clone 114-6G6
Isotype IgG1
Specificity The antibody specifically reacts with hMT1-MMP.
Purification Purified
Alternative Name MMP-14 (MMP14 Antibody Abstract)
Background The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane-type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis. MMP14 may be an activator of pro gelatinase A and is expressed in fibroblast cells during both wound healing and human cancer progression. MMP14 is expressed in very low levels and may require stimulation with concanavolin A or the phorbol ester TPA to stimulate production of MMP14.Synonyms: MMP-X1, MMP14, Matrix metalloproteinase-14, Membrane-type-1 matrix metalloproteinase
Gene ID 4323
Research Area Cancer, Extracellular Matrix, Inflammation
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer 0.1 M Sodium Phosphate buffer, pH 7.0, 0.5 % protease-free BSA
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-MMP14 antibody (Matrix Metallopeptidase 14 (Membrane-inserted)) (ABIN567587) Mouse anti-MT1-MMP (Catalog Number AF8610) Staining of breast carcinoma.
Background publications Ueno, Nakamura, Inoue, Imai, Noguchi, Sato, Seiki, Okada: "Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas." in: Cancer research, Vol. 57, Issue 10, pp. 2055-60, 1997 (PubMed).

Sato, Takino, Okada, Cao, Shinagawa, Yamamoto, Seiki: "A matrix metalloproteinase expressed on the surface of invasive tumour cells." in: Nature, Vol. 370, Issue 6484, pp. 61-5, 1994 (PubMed).