Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (AA 262-319) antibody

Details for Product No. ABIN567775
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Antigen
Synonyms
nemo, fj33c07, wu:fj33c07, zgc:113492, MGC97885, IKBKG, IKBKG_1, IKBKG_2, CG16910, DmIKK-gamma, DmIKKgamma, Dmel\\CG16910, Dmikkgamma, IKK, IKK-gamma, IKK[[gamma]], IKKg, IKKgamma, KEY, Kenny, Key, dI ... show more
nemo, fj33c07, wu:fj33c07, zgc:113492, MGC97885, IKBKG, IKBKG_1, IKBKG_2, CG16910, DmIKK-gamma, DmIKKgamma, Dmel\\CG16910, Dmikkgamma, IKK, IKK-gamma, IKK[[gamma]], IKKg, IKKgamma, KEY, Kenny, Key, dIKK, dIKK-gamma, dmIKKgamma, AMCBX1, FIP-3, FIP3, Fip3p, IP, IP1, IP2, IPD2, NEMO, ZC2HC9, Nemo, 1110037D23Rik, AI848108, AI851264, AW124339, IKK[g] show less
Epitope
AA 262-319
(28), (26), (26), (24), (16), (12), (12), (11), (7), (5), (5), (5), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(270), (60), (49), (4), (3), (3), (2), (2), (2), (2), (2), (1), (1)
Host
Mouse
(226), (50), (3), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(10), (9), (9), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
(209), (116), (63), (50), (35), (30), (16), (6), (5), (3), (2), (1), (1), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Immunogen Human recombinant GST-IKKG (a.a. 262-319).
Clone EA2-6
Isotype IgG1
Specificity This antibody reacts with IKKG (45 kDa) on Western blotting.
Purification Protein-A Agarose Chromatography of hybridoma supernatant.
Alternative Name NEMO / IKBKG (IKBKG Antibody Abstract)
Background The I-kB kinase complex (IKK) functions as a mediator of NF-kB activation in response to multiple stimuli by phosphorylating I-kB inhibitor proteins and causing their degradation. IKK contains two structurally related catalytic subunits termed IKKA and IKKB as well as a noncatalytic subunit called IKKG/NEMO. IKK is composed of a IKKG/NEMO homodimer bound together with either an IKKA/IKKB heterodimer or an IKKB homodimer. Although IKKG /NEMO itself does not have kinase activity, it is essential for NF-kB activation likely via a scaffold function that is required for IKK activity. Mutations in the X-linked gene encoding IKKG can interfere with NF-kB signaling and lead to immunodeficiency disease.Synonyms: FIP-3, FIP3, I-kappa-B kinase subunit gamma, IKK-gamma, IKKAP1, IKKG, IkB kinase subunit gamma, IkB kinase-associated protein 1, Inhibitor of nuclear factor kappa-B kinase subunit gamma, NF-kappa-B essential modifier, NF-kappa-B essential modulator
Gene ID 8517
NCBI Accession NP_001093326
UniProt Q9Y6K9
Pathways NF-kappaB Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS, pH 7.2 containing 50 % Glycerol without preservatives.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C.
Supplier Images
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (AA 262-319) antibody anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (AA 262-319) antibody
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (AA 262-319) antibody (2) anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (AA 262-319) antibody (Image 2)
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (AA 262-319) antibody (3) anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (AA 262-319) antibody (Image 3)
Background publications Iha, Kibler, Yedavalli et al.: "Segregation of NF-kappaB activation through NEMO/IKKgamma by Tax and TNFalpha: implications for stimulus-specific interruption of oncogenic signaling." in: Oncogene, Vol. 22, Issue 55, pp. 8912-23, 2003 (PubMed).

Chu, Shin, Yang et al.: "IKKgamma mediates the interaction of cellular IkappaB kinases with the tax transforming protein of human T cell leukemia virus type 1." in: The Journal of biological chemistry, Vol. 274, Issue 22, pp. 15297-300, 1999 (PubMed).

Validation Images
Catalog No. ABIN567775
346.50 $
Plus shipping costs $45.00
Quantity
Price
0.1 mg
346.50 $

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