Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

Caspase 12 antibody (N-Term)

CASP12 Reactivity: Human, Mouse, Rat WB, IHC (p), IF, IP Host: Rat Monoclonal 14F7 unconjugated
Catalog No. ABIN567795
  • Target See all Caspase 12 (CASP12) Antibodies
    Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))
    Binding Specificity
    • 16
    • 15
    • 8
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 95-318, N-Term
    Reactivity
    Human, Mouse, Rat
    Host
    • 89
    • 2
    • 1
    Rat
    Clonality
    • 90
    • 2
    Monoclonal
    Conjugate
    • 39
    • 8
    • 6
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This Caspase 12 antibody is un-conjugated
    Application
    • 78
    • 40
    • 29
    • 28
    • 26
    • 26
    • 20
    • 18
    • 10
    • 6
    • 5
    • 4
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunoprecipitation (IP)
    Specificity
    This antibody reacts with Caspase-12 (~53 kDa) on Western blotting, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry.
    Purification
    Protein-G Agarose Chromatography of hybridoma supernatant.
    Immunogen
    Recombinant Caspase-12 N-terminal fragment (aa 95-318).
    Clone
    14F7
    Isotype
    IgG2a
    Top Product
    Discover our top product CASP12 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS, pH 7.2 containing 50 % Glycerol without preservatives.
    Preservative
    Without preservative
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store the antibody (in aliquots) at -20 °C.
  • Target
    Caspase 12 (CASP12) (Caspase 12 (Gene/pseudogene) (CASP12))
    Alternative Name
    Caspase-12 (CASP12 Products)
    Synonyms
    Caspase-12 antibody, CASP-12 antibody, CASP12P1 antibody, caspase 12 antibody, caspase 12 (gene/pseudogene) antibody, Casp12 antibody, CASP12 antibody
    Background
    Caspase-12 is localized to the endoplasmic reticulum (ER), but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis and accumulation of excess proteins in ER, but not by membrane- or mitochondrial-targeted apoptotic signals. One well-known cause of ER stress in neurons is the accretion of amyloid-beta, the insoluble protein that forms plaques in the brains of patients with Alzheimer's disease. Caspase-12 mediates cytotoxicity induced by amyloid-beta and ER stress-induced apoptosis. Caspase-12 is ubiquitously expressed in tissues. Similar to other members of the Caspase family, Caspase-12 requires cleavage of the prodomain to activate its proapoptotic form.Synonyms: CASP-12, CASP12, Inactive caspase-12
    Gene ID
    100506742
    NCBI Accession
    NP_001177945
    UniProt
    Q6UXS9
    Pathways
    Apoptosis, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
You are here:
Support