V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) (AA 106-123) antibody

Details for Product No. ABIN567803
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Antigen
Epitope
AA 106-123
(54), (21), (17), (17), (13), (11), (7), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(253), (110), (96), (22), (21), (20), (20), (12), (3), (2), (2), (2), (2), (1), (1)
Host
Mouse
(194), (52), (10), (2), (2), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(9), (9), (9), (8), (7), (7), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application
Western Blotting (WB)
(223), (125), (95), (41), (39), (34), (28), (15), (13), (10), (3), (1)
Pubmed 4 references available
Quantity 0.2 mL
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Catalog No. ABIN567803
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Immunogen Synthetic peptide corresponding to amino acids 106-123 of Human AKT2.
Sequence VANSLKQRAP GEDPMDYK
Clone 95C657-1-2
Isotype IgM
Specificity Recognizes AKT2
Purification Ascites
Alternative Name AKT2 / PKB beta
Background AKT, protein kinase B (PKB), is a serine/threonine kinase, which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI 3-kinase). AKT2 is amplified and overexpressed in some human cancers. AKT2 encodes a RAC/AKT-type protein kinase that contains a N-terminal pleckstrin- homology (PH) domain and a central catalytic domain closely related to both cAMP- dependent protein kinase and protein kinase C. The protein is a member of PI3K-mediated signalling pathways associated with the regulation of proliferation, survival, protein synthesis, and metabolism. It is activated by a variety of growth factors. AKT2 has been shown to be transcriptionally regulated by MyoD and to activate MyoD-myocyte enhancer binding factor-2 (MEF2) transactivation activity during muscle differentiation. Glycogen synthase kinase 3 (GSK-3) also has been shown to be a downstream target of AKT2. The AKT2 gene is one of the human homologues of v-akt, the transduced oncogene of the AKT8 virus, which induces lymphomas in mice. It has been implicated in breast, ovarian, and pancreatic cancers.
Alternate names: Protein kinase Akt-2, Protein kinase B beta, RAC-PK-beta, RAC-beta serine/threonine- protein kinase
Gene ID 208
NCBI Accession NP_001617
UniProt P31751
Research Area Signaling
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.05% BSA and 0.05% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C to -70°C for longer.
Expiry Date 12 months
Supplier Images
anti-V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) (AA 106-123) antibody anti-V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) (AA 106-123) antibody
Background publications Cheng, Godwin, Bellacosa et al.: "AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 19, pp. 9267-71, 1992 (PubMed).

Cheng, Ruggeri, Klein et al.: "Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 8, pp. 3636-41, 1996 (PubMed).

Alessi, Andjelkovic, Caudwell et al.: "Mechanism of activation of protein kinase B by insulin and IGF-1." in: The EMBO journal, Vol. 15, Issue 23, pp. 6541-51, 1997 (PubMed).

Kandel, Hay: "The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB." in: Experimental cell research, Vol. 253, Issue 1, pp. 210-29, 1999 (PubMed).

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