CD19 Molecule (CD19) antibody

Details for Product No. ABIN567825
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(567), (377), (31), (12), (2)
(527), (223), (145), (10), (2)
Clonality (Clone)
Monoclonal ()
(115), (112), (84), (60), (17), (15), (14), (13), (12), (11), (10), (9), (8), (8), (6), (6), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS)
(702), (155), (135), (127), (92), (48), (44), (41), (37), (24), (19), (10), (7), (4), (4), (3), (2), (1), (1), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN567825
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Clone CB19
Isotype IgG1
Specificity This antibody recognizes CD19.
Purification Protein G Chromatography
Alternative Name CD19
Background CD19 is a member of the immunoglobulin superfamily with 556 amino acid and two immunoglobulin-like C2-type domains. As a cell surface protein, CD19 is known to form a complex with CD21, CD81 and CD225 in the membrane of mature B cells. A major function of CD19 is to assemble with the antigen receptor of B lymphocytes so as to decrease the threshold for antigen receptor dependent stimulation thus enhancing the specificity and sensitivity of B cells towards antigens. CD19 is an important protein for B cell antigen receptor signaling and regulation and also acts as a specialized adaptor protein for the amplification of Src family needed for this purpose. Regulation of growth of B cells is a major function of CD19 and its expression is confined to only B lymphocytes and follicular dendritic cells of the hematopoietic system. Increased expression of CD19 induces the production of autoantibody thus giving an insight to the regulatory role of CD19 in autoimmunity. Defects in CD19 are a cause of hypogammaglobulinemia.
Alternate names: B-cell marker, B-lymphocyte surface antigen B4, Differentiation antigen CD19, Leu-12
Gene ID 930
NCBI Accession NP_001171569
UniProt P15391
Research Area Stem Cells, Hematopoietic Progenitors, Hematopoietic Stem Cells, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS, 0.05% Sodium Azide 0.05% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-CD19 Molecule (CD19) antibody anti-CD19 Molecule (CD19) antibody
Background publications van Zelm, Reisli, van der Burg et al.: "An antibody-deficiency syndrome due to mutations in the CD19 gene." in: The New England journal of medicine, Vol. 354, Issue 18, pp. 1901-12, 2006 (PubMed).

Fujimoto, Fujimoto, Poe et al.: "CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification." in: Immunity, Vol. 13, Issue 1, pp. 47-57, 2000 (PubMed).

Carter, Fearon: "CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes." in: Science (New York, N.Y.), Vol. 256, Issue 5053, pp. 105-7, 1992 (PubMed).

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