CAMP Responsive Element Binding Protein 1 (CREB1) antibody (Biotin)

Details for Product No. ABIN567865
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Antigen
Reactivity
Human
(410), (265), (251), (75), (68), (67), (45), (8), (5), (5), (4), (1), (1), (1), (1), (1)
Host
Mouse
(370), (57), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Biotin
(12), (10), (10), (7), (6), (6), (6), (6), (6), (6), (6), (2), (2), (2)
Application
ELISA
(328), (182), (161), (74), (60), (51), (32), (25), (22), (15), (11), (5), (2), (2), (2), (2), (1), (1)
Pubmed 9 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN567865
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Immunogen Synthetic peptide of Human CREB.
Clone 82B514-2
Isotype IgG1
Specificity Recognizes cAMP Response Element Binding Protein (CREB).
Purification Protein G Chromatography
Alternative Name CREB1
Background The transcription factor cAMP response element binding (CREB) binds the palindromic octanucleotide TGACGTCA (8,9). Members of ATF/CREB family include CREB-1, CREB-2 (also designated ATF-4), ATF-1, ATF-2 and ATF-3 (3-7). These proteins share highly conserved leucine zipper dimerization and basic DNA binding domains at the COOH terminal but are highly divergent in their amino terminal domains (5). CREB-1 is phosphorylated at Ser133, a key regulatory site controlling transcriptional activity, by many different kinases including protein kinase A, the calmodulin-dependent protein kinase CaMKII, p44/42 MAP kinase, p90RSK, p38 MAP kinase and MSK1 (2). Phosphorylation allows recruitment of CREB- binding protein (CBP), a large co-activator that contacts the general transcriptional machinery. CREB-mediated transcription regulates diverse cellular responses, including intermediary metabolism, neuronal signaling, cell proliferation, and apoptosis (1).
Alternate names: CREB-1, Cyclic AMP-responsive element-binding protein 1, cAMP-responsive element- binding protein 1
Gene ID 1385
NCBI Accession NP_004370
UniProt P16220
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.02% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice DO NOT FREEZE!
Storage 4 °C
Storage Comment Store the antibody at 2-8°C
Expiry Date 12 months
Background publications Karpinski, Morle, Huggenvik et al.: "Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 11, pp. 4820-4, 1992 (PubMed).

Hai, Curran: "Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 9, pp. 3720-4, 1991 (PubMed).

Kara, Liou, Ivashkiv et al.: "A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain." in: Molecular and cellular biology, Vol. 10, Issue 4, pp. 1347-57, 1990 (PubMed).

Hai, Liu, Coukos et al.: "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers." in: Genes & development, Vol. 3, Issue 12B, pp. 2083-90, 1990 (PubMed).

Gonzalez, Montminy: "Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133." in: Cell, Vol. 59, Issue 4, pp. 675-80, 1990 (PubMed).

Montminy, Sevarino, Wagner et al.: "Identification of a cyclic-AMP-responsive element within the rat somatostatin gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 18, pp. 6682-6, 1986 (PubMed).

Hoeffler, Meyer, Yun et al.: "Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA." in: Science (New York, N.Y.), Vol. 242, Issue 4884, pp. 1430-3, 1989 (PubMed).

Andrisani: "CREB-mediated transcriptional control." in: Critical reviews in eukaryotic gene expression, Vol. 9, Issue 1, pp. 19-32, 1999 (PubMed).

De Cesare, Fimia, Sassone-Corsi: "Signaling routes to CREM and CREB: plasticity in transcriptional activation." in: Trends in biochemical sciences, Vol. 24, Issue 7, pp. 281-5, 1999 (PubMed).

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