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HtrA Serine Peptidase 2 (HTRA2) (AA 335-350) antibody

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AA 335-350
(20), (16), (14), (9), (7), (4), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(136), (38), (34), (1), (1), (1)
(102), (34)
Clonality (Clone)
Monoclonal ()
(6), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(105), (68), (50), (20), (20), (11), (4), (4), (3), (2), (1), (1), (1), (1)
Pubmed 6 references available
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Quantity 0.1 mg
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Immunogen Immunizing mice with a synthetic peptide containing amino acids 335-350 of Human Omi/HtrA2.
Clone 196C429
Isotype IgG1
Specificity Recognizes Human Omi/HtrA2. It does not cross-react with Mouse Omi/HtrA2.
Purification Protein G Chromatography
Alternative Name HTRA2 / PRSS25 (HTRA2 Antibody Abstract)
Background The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity (1-3). Recently, a serine protease has been isolated, which is released from the mitochondria upon induction of apoptosis by apoptotic stimuli. This protein called Omi/HtrA2 is a mitochondrial protein that binds to IAP (4). Like Smac/DIABLO, the mature Omi protein contains a conserved IAP-binding motif (AVPS) at its N terminus. The deregulated expression of Omi in the cytoplasm of mammalian cells induces apoptosis indicating that Omi could participate in the mitochondrial apoptotic pathway.
Alternate names: High temperature requirement protein A2, OMI, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI, mitochondrial Serine protease HTRA2
Gene ID 27429
NCBI Accession NP_037379
UniProt O43464
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.02% Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
Immunohistochemistry (IHC) image for anti-HtrA Serine Peptidase 2 (HTRA2) (AA 335-350) antibody (ABIN567900) anti-HtrA Serine Peptidase 2 (HTRA2) (AA 335-350) antibody
Western Blotting (WB) image for anti-HtrA Serine Peptidase 2 (HTRA2) (AA 335-350) antibody (ABIN567900) anti-HtrA Serine Peptidase 2 (HTRA2) (AA 335-350) antibody (Image 2)
Background publications Wang, Zhu, Wang et al.: "X-linked inhibitor of apoptosis (XIAP) protein protects against caspase activation and tissue loss after neonatal hypoxia-ischemia." in: Neurobiology of disease, Vol. 16, Issue 1, pp. 179-89, 2004 (PubMed).

Lee, Lee, Kim et al.: "Immunohistochemical analysis of Omi/HtrA2 expression in stomach cancer." in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 111, Issue 5, pp. 586-90, 2003 (PubMed).

Hegde, Srinivasula, Zhang et al.: "Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 432-8, 2002 (PubMed).

Reed, Bischoff: "BIRinging chromosomes through cell division--and survivin' the experience." in: Cell, Vol. 102, Issue 5, pp. 545-8, 2000 (PubMed).

Miller: "An exegesis of IAPs: salvation and surprises from BIR motifs." in: Trends in cell biology, Vol. 9, Issue 8, pp. 323-8, 1999 (PubMed).

Deveraux, Reed: "IAP family proteins--suppressors of apoptosis." in: Genes & development, Vol. 13, Issue 3, pp. 239-52, 1999 (PubMed).

Catalog No. ABIN567900

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