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Details for Product No. ABIN567903

conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) antibody

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Antigen
Synonyms IKK1, IKKA, IKBKA, TCF16, NFKBIKA, IKK-alpha, AI256658, Chuk1, Fbx24, Fbxo24, Ikka, ikk, ikk1, ikka, ikkalpha, CHUK
Reactivity
»Alternatives Human, Monkey, Mouse (Murine)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB), Flow Cytometry (FACS)
Pubmed 3 references available
Catalog no. ABIN567903
Quantity 0.1 mg
Price
489.50 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 6 to 8 Business Days
Immunogen His-tagged full-length Human IKKa/IKK1 protein
Clone 14A231
Isotype IgG1
Specificity This antibody was raised against a His-tagged full-length Human IKKa/IKK1 protein.
Purification Protein G Chromatography
Alternative Name IKKA
Background NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing translocation of NF-kB to the nucleus. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g. In vitro, IKK1/a and IKK2/b can form homo- and heterodimers that can phosphorylate IkBs at the regulatory serine residues directly. IKK1/a and IKK2/b are phosphorylated by NF-kB-inducing kinase (NIK) and MAP kinase kinase kinase-1 (MEKK1) (1), respectively. Targeted disruption of IKK1/a gene in mice results in skin and limb abnormalities and death of newborns (2,3).
Alternate names: CHUK, Conserved helix-loop-helix ubiquitous kinase, I kappa-B kinase alpha, I-kappa-B kinase 1, IKK-A, IKK-alpha, IKK1, IkBKA, IkappaB kinase, Inhibitor of nuclear factor kappa-B kinase subunit alpha, NFKBIKA, Nuclear factor NF-kappa-B inhibitor kinase alpha, TCF16
Gene ID 1147
NCBI Accession NP_001269.3
UniProt O15111
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.02% Sodium Azide as preservative
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Delhase, Hayakawa, Chen et al.: "Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation." in: Science (New York, N.Y.), Vol. 284, Issue 5412, pp. 309-13, 1999 (PubMed).

Takeda, Takeuchi, Tsujimura et al.: "Limb and skin abnormalities in mice lacking IKKalpha." in: Science (New York, N.Y.), Vol. 284, Issue 5412, pp. 313-6, 1999 (PubMed).

Hu, Baud, Delhase et al.: "Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase." in: Science (New York, N.Y.), Vol. 284, Issue 5412, pp. 316-20, 1999 (PubMed).

Alternatives for antigen "conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK)", type "Antibodies"
Hosts (213), (41), (1)
Reactivities (252), (108), (103), (48), (24), (24), (24), (12)
Applications (204), (97), (56), (48), (40), (39), (30), (29), (6), (3), (2), (1), (1), (1)
Conjugates (6), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Epitopes (33), (21), (19), (16), (12), (9), (9), (7), (5), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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