conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) antibody

Details for Product No. ABIN567903
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Antigen
Reactivity
Human, Monkey, Mouse (Murine)
(263), (101), (94), (48), (24), (24), (24), (12), (1)
Host
Mouse
(224), (42), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(10), (8), (8), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Application
Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB), Flow Cytometry (FACS)
(223), (111), (59), (43), (40), (39), (30), (26), (6), (3), (2), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN567903
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Immunogen His-tagged full-length Human IKKa/IKK1 protein
Clone 14A231
Isotype IgG1
Specificity This antibody was raised against a His-tagged full-length Human IKKa/IKK1 protein.
Purification Protein G Chromatography
Alternative Name IKKA
Background NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing translocation of NF-kB to the nucleus. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g. In vitro, IKK1/a and IKK2/b can form homo- and heterodimers that can phosphorylate IkBs at the regulatory serine residues directly. IKK1/a and IKK2/b are phosphorylated by NF-kB-inducing kinase (NIK) and MAP kinase kinase kinase-1 (MEKK1) (1), respectively. Targeted disruption of IKK1/a gene in mice results in skin and limb abnormalities and death of newborns (2,3).
Alternate names: CHUK, Conserved helix-loop-helix ubiquitous kinase, I kappa-B kinase alpha, I-kappa-B kinase 1, IKK-A, IKK-alpha, IKK1, IkBKA, IkappaB kinase, Inhibitor of nuclear factor kappa-B kinase subunit alpha, NFKBIKA, Nuclear factor NF-kappa-B inhibitor kinase alpha, TCF16
Gene ID 1147
NCBI Accession NP_001269
UniProt O15111
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS containing 0.02% Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) antibody anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) antibody
anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) antibody (2) anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) antibody (Image 2)
anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) antibody (3) anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) antibody (Image 3)
Background publications Delhase, Hayakawa, Chen et al.: "Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation." in: Science (New York, N.Y.), Vol. 284, Issue 5412, pp. 309-13, 1999 (PubMed).

Takeda, Takeuchi, Tsujimura et al.: "Limb and skin abnormalities in mice lacking IKKalpha." in: Science (New York, N.Y.), Vol. 284, Issue 5412, pp. 313-6, 1999 (PubMed).

Hu, Baud, Delhase et al.: "Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase." in: Science (New York, N.Y.), Vol. 284, Issue 5412, pp. 316-20, 1999 (PubMed).

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