RAR-Related Orphan Receptor C (RORC) (AA 1-50), (N-Term) antibody

Details for Product No. ABIN567938
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Antigen
Epitope
AA 1-50, N-Term
(17), (17), (7), (6), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Monkey, Mouse (Murine)
(106), (58), (29), (28), (27), (24), (12)
Host
Mouse
(84), (19), (6), (3), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application
Western Blotting (WB), Flow Cytometry (FACS)
(75), (33), (20), (18), (11), (7), (6), (4), (2), (2), (2), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Discontinued
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Catalog No. ABIN567938
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Immunogen A portion of amino acids 1-50 of human RORg
Clone 4G419
Isotype IgG1
Specificity This antibody will detect RORg and may detect RORgt, but can not be used to distinguish between the two proteins.
Purification Affinity Chromatography
Alternative Name ROR-gamma / RORC
Background ROR-gamma is a 560 amino acid novel DNA-binding transcription factor belonging to the ROR/RZR orphan nuclear receptor subfamily. The specific functions of this protein are not known. However, reports suggest that this protein is a ligand activated transcription factor and may be essential for lymphoid organogenesis (lymph nodes and Peyer's patches) and may play an important regulatory role in controlling apoptosis during thymopoiesis. ROR- gamma inhibits the expression of Fas ligand and IL2 and directs the differentiation program of proinflammatory IL-17+ T helper cells. ROR-gamma shares 50 to 51% sequence identity with RORA and RORB and is 88% identical to mouse ROR-gamma. It is highly expressed in skeletal muscle and at lower levels in various other tissues.
Alternate names: NR1F3, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, RORG, RZRG, Retinoid-related orphan receptor-gamma
Gene ID 6097
NCBI Accession NP_001001523
UniProt P51449
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer PBS containing 0.05% BSA and 0.05% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-RAR-Related Orphan Receptor C (RORC) (AA 1-50), (N-Term) antibody anti-RAR-Related Orphan Receptor C (RORC) (AA 1-50), (N-Term) antibody
anti-RAR-Related Orphan Receptor C (RORC) (AA 1-50), (N-Term) antibody (2) anti-RAR-Related Orphan Receptor C (RORC) (AA 1-50), (N-Term) antibody (Image 2)
anti-RAR-Related Orphan Receptor C (RORC) (AA 1-50), (N-Term) antibody (3) anti-RAR-Related Orphan Receptor C (RORC) (AA 1-50), (N-Term) antibody (Image 3)
Background publications Hirose, Smith, Jetten: "ROR gamma: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle." in: Biochemical and biophysical research communications, Vol. 205, Issue 3, pp. 1976-83, 1995 (PubMed).

Kurebayashi, Ueda, Sakaue et al.: "Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 18, pp. 10132-7, 2000 (PubMed).

Eberl, Marmon, Sunshine et al.: "An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells." in: Nature immunology, Vol. 5, Issue 1, pp. 64-73, 2003 (PubMed).

Ivanov, McKenzie, Zhou et al.: "The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells." in: Cell, Vol. 126, Issue 6, pp. 1121-33, 2006 (PubMed).

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