Sphingosine Kinase 1 (SPHK1) (C-Term) antibody

Details for Product No. ABIN568023
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Antigen
Synonyms CG1747, Dmel\\CG1747, SK1, Sphk1, SPHK1, F18E5.160, F18E5_160, sphingosine kinase 1, SPHK, 1110006G24Rik, Sk1, Spk1
Epitope
C-Term
(21), (8), (6), (6), (3), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(95), (32), (32), (15), (13), (2), (1)
Host
Goat
(96), (10), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(78), (29), (22), (14), (13), (10), (6), (4), (4), (3), (2)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN568023
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Immunogen Peptide from C Terminus of the protein sequence according to according to NP_068807.2, NP_892010.2, NP_001136073.1. Genename: SPHK1
Sequence C-SWKPQQMPPP EEPL
Specificity This antibody detects Sphingosine Kinase 1 at C-term. This antibody is expected to recognize all reported isoforms (NP_068807.2, NP_892010.2 and NP_001136073.1). Species Reactivity: Tested: Human.
Purification Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Background SPHK1 catalyzes the phosphorylation of sphingosine to form sphingosine 1 phosphate (SPP), a lipid mediator which has both intra- and extracellular functions. Intracellularly, SPP regulates proliferation and survival. Extracellularly it functions as a ligand for EDG1. SPHK1 also acts on D erythro sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. Competitive inhibitors of SPHK block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors, including platelet derived growth factor and serum. SPHK1 has also been found to mediate TRAF2 activation (Xia et al 2002). TRAF2 is a member of the TNF receptor associated family and is required for TNF alpha activation of MAPK8/JNK and NFkB. SPHK1 is widely expressed, with highest levels in adult liver, kidney, heart and skeletal muscle.
Alternate names: SPHK, SPK, SPK 1, SPK-1
Gene ID 8877
NCBI Accession NP_068807
UniProt Q9NYA1
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, pH~7.3 with 0.02% Sodium Azide and 0.5% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Sphingosine Kinase 1 (SPHK1) (C-Term) antibody anti-Sphingosine Kinase 1 (SPHK1) (C-Term) antibody
Background publications Kohama, Olivera, Edsall et al.: "Molecular cloning and functional characterization of murine sphingosine kinase." in: The Journal of biological chemistry, Vol. 273, Issue 37, pp. 23722-8, 1998 (PubMed).

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